CC BY-NC-ND 4.0 · Eur J Dent 2013; 07(01): 212-215
DOI: 10.1055/s-0039-1700382
Original Article
Dental Investigation Society

Inducible Nitric Oxide Expression Correlates with the Level of Inflammation in Periapical Cysts

Mariza Akemi Matsumotoa Assistant Prof,PhD DMD
a   Department of Oral and Maxillofacial Surgery, University of Sacred Heart, USC, Bauru, SP
Daniel Araki Ribeirob Research Assistant
b   Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP
› Author Affiliations
Further Information

Publication History

Publication Date:
30 September 2019 (online)


Objectives: In an attempt to elucidate if inducible nitric oxide expression (iNOS) is correlated with the level of inflammation in periapical cysts with accuracy, the goal of this study was to evaluate the expression of iNOS in these ones.

Methods: 30 cases were included in this study being iNOS evaluated by means of immunohistochemistry. Statistical analysis was performed by Kruskal-Wallis non-parametric test followed by the post-hoc Dunn’s test.

Results: iNOS stain was detected throughout the epithelium, subepithelial fibroblasts and macrophages in all cases, indistinctly. Nevertheless, iNOS immunostaining in periapical cysts was different according to the levels of inflammation, being the strongest effect associated with intense inflammatory infiltrate.

Conclusions: Taken together, our results indicate that immunoreactivity of iNOS was expressed in several cellular types present in periapical cyst, being positively correlated with the level of inflammation. Therefore, iNOS expression plays an important role in the pathogenesis of periapical cysts. (Eur J Dent 2007;1:212-215)

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