CC BY-NC-ND 4.0 · Eur J Dent 2019; 13(04): 649-653
DOI: 10.1055/s-0039-1700363
Case Report
Dental Investigation Society

Pleomorphic Adenoma in the Lower Lip: A Case Report and a Review

1   Department of Oral and Maxillofacial Surgery, College of Dentistry, Taibah University, Al Madinah Al Munawara, Saudi Arabia
,
2   Department of Oral Basic and Clinical Sciences, College of Dentistry, Taibah University, Al Madinah Al Munawara, Saudi Arabia
3   Department of Oral Surgery, Oral Medicine and Periodontics, School of Dentistry, University of Jordan, Amman, Jordan
› Author Affiliations
Funding None.
Further Information

Publication History

Publication Date:
13 November 2019 (online)

Abstract

Pleomorphic adenoma constitutes 50% of salivary gland tumors affecting mostly the parotid gland extraorally, and the palate intraorally. While the upper lip is a common site, it is unusual to encounter this tumor in the lower lip. A 26-year-old man complained of a persistent lump affecting the lower lip. The lesion was excised and was shown on histopathological examination to be a pleomorphic adenoma with squamous metaplasia. At the 18-month review appointment, there was complete healing and no recurrence. Pleomorphic adenoma in the lower lip should be considered among the differential diagnosis of lower labial swellings, especially in young patients. There needs to be reconsideration of the epidemiological and histological characteristics.

 
  • References

  • 1 Speight PM, Barrett AW. Salivary gland tumours. Oral Dis 2002; 8 (05) 229-240
  • 2 Eveson JW, Cawson RA. Tumours of the minor (oropharyngeal) salivary glands: a demographic study of 336 cases. J Oral Pathol 1985; 14 (06) 500-509
  • 3 Jorge J, Pires FR, Alves FA. et al. Juvenile intraoral pleomorphic adenoma: report of five cases and review of the literature. Int J Oral Maxillofac Surg 2002; 31 (03) 273-275
  • 4 Sengul I, Sengul D. Pleomorphic adenoma of the lower lip: a review. N Am J Med Sci 2011; 3 (12) 536-539
  • 5 Sood A, Chung S, Datiashvili RO. An incidental finding of pleomorphic adenoma of the minor salivary glands in the skin area of the lower lip. Eplasty 2014; 14: e39
  • 6 To EWH, Tsang WM, Tse GMK. Pleomorphic adenoma of the lower lip: report of a case. J Oral Maxillofac Surg 2002; 60 (06) 684-686
  • 7 Yamamoto H, Fukumoto M, Matsumoto T. et al. Pleomorphic adenoma of the lower lip: a case and review of the Japanese literature. J Nihon Univ Sch Dent 1985; 27 (03) 189-194
  • 8 Taniguchi K, Naito H, Mori K, Kawano M, Nakashima T. A case of pleomorphic adenoma of the lower lip Japanese J Oral Diagnosis/Oral Med 2016; 26 (02) 86-91
  • 9 Adachi M, Yoshino A, Yanai C, Shirakawa M, Nonaka H. A case of pleomorphic adenoma of the lower lip Japanese J Oral Maxillofac Surg 2011; DOI: 10.5794/jjoms.44.61.
  • 10 Alves VLA, Pérez-de-Oliveira ME, de Castro JFL, Vieira CL, Leão JC, Perez DEC. Intraoral pleomorphic adenoma in young patients. J Craniofac Surg 2018; 29 (02) e209-e211
  • 11 Mair Y, Aguirre A. Upper lip swelling. J Am Dent Assoc 2016; 147 (11) 898-901
  • 12 Khan MN, Raza SS, Hussain Zaidi SA. et al. Pleomorphic adenoma of minor salivary glands. J Ayub Med Coll Abbottabad 2016; 28 (03) 620-622
  • 13 Fatahzadeh M. Pleomorphic adenoma of the upper lip: a rare case. N Y State Dent J 2017; 83 (02) 47-51
  • 14 Ahmedi JR, Ahmedi E, Perjuci F. et al. Pleomorphic adenoma of minor salivary glands in child. Med Arh 2017; 71 (05) 360-363
  • 15 Fomete B, Adeosun OO, Awelimobor DI, Olayemie L. Recurrent pleomorphic adenoma of the upper lip: case report and review of the literature. Niger J Med 2015; 24 (03) 277-280
  • 16 Mariano FV, Rincon D, Gondak RO. et al. Carcinoma ex-pleomorphic adenoma of upper lip showing copy number loss of tumor suppressor genes. Oral Surg Oral Med Oral Pathol Oral Radiol 2013; 116 (01) 69-74
  • 17 Singh A, Kumar N, Sharma P, Singh S. Pleomorphic adenoma involving minor salivary glands of upper lip: a rare phenomenon. J Cancer Res Ther 2015; 11 (04) 1025
  • 18 Mitate E, Kawano S, Kiyoshima T. et al. Carcinoma ex pleomorphic adenoma of the upper lip: a case of an unusual malignant component of squamous cell carcinoma. World J Surg Oncol 2013; 11: 234
  • 19 Küçük Ü, Tan S. Pleomorphic adenoma of the upper lip. Turk Patoloji Dergisi/Turkish. J Pathol 2011; 4 (03) 217-219
  • 20 Taiwo AO, Akinshipo A, Braimah ROIA, Ibikunle AA. Pleomorphic adenoma of the upper lip: a case report. Saudi J Med Med Sci 2018; 6 (01) 32-35
  • 21 Stander S, Mulder-Van Staden S, Cheung TY, Dreyer WP, Mohamed N, Afrogheh A. Oral medicine case book 52: pleomorphic adenoma of the upper lip. SADJ 2013; 68 (07) 328-330
  • 22 Tzermpos F, Chatzichalepli C, Cocos A, Kleftogiannis M, Zarakas M, Chrysomali E. Atypical presentation of an upper lip pleomorphic adenoma: case report. Acta Stomatol Croat 2014; 48 (01) 48-53
  • 23 Lotufo MA, Júnior CAL, Mattos JP, França CM. Pleomorphic adenoma of the upper lip in a child. J Oral Sci 2008; 50 (02) 225-228
  • 24 Asuquo ME, Otei OO, Ekpo R. et al. Salivary gland tumour of the lip: report of two cases and literature review. Cent Afr J Med 2009; 55 (05) (08) 43-46
  • 25 Dyalram D, Huebner T, Papadimitriou JC, Lubek J. Carcinoma ex pleomorphic adenoma of the upper lip. Int J Oral Maxillofac Surg 2012; 41 (03) 364-367
  • 26 McNamara ZJ, Batstone M, Farah CS. Carcinoma ex pleomorphic adenoma in a minor salivary gland of the upper lip Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108 (05) e51-e53
  • 27 Kataria SP, Tanwar P, Sethi D, Garg M. Pleomorphic adenoma of the upper lip. J Cutan Aesthet Surg 2011; 4 (03) 217-219
  • 28 Ali I, Gupta AK, Singh S. Pleomorphic adenoma of the upper lip. Natl J Maxillofac Surg 2011; 2 (02) 219-221
  • 29 Debnath SC, Adhyapok AK. Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip. J Maxillofac Oral Surg 2010; 9 (02) 205-208
  • 30 Sengul I, Sengul D, Aribas D. Pleomorphic adenoma of the lower lip: a rare site of location. N Am J Med Sci 2011; 3 (06) 299-301
  • 31 Katabi N, Xu B. Salivary gland neoplasms: diagnostic approach with focus on patterns of recognition and useful ancillary tools. Diagn Histopathol 2018; 00
  • 32 Katabi N, Xu B, Jungbluth AA. et al. PLAG1 immunohistochemistry is a sensitive marker for pleomorphic adenoma: a comparative study with PLAG1 genetic abnormalities. Histopathology 2018; 72 (02) 285-293
  • 33 Lam KY, Ng IO, Chan GS. Palatal pleomorphic adenoma with florid squamous metaplasia: a potential diagnostic pitfall. J Oral Pathol Med 1998; 27 (08) 407-410
  • 34 Sridevi U, Jain A, Nagalaxmi V, Kumar UV, Goyal S. Expression of E-cadherin in normal oral mucosa, in oral precancerous lesions and in oral carcinomas. Eur J Dent 2015; 9 (03) 364-372
  • 35 Hamada T, Matsukita S, Goto M. et al. Mucin expression in pleomorphic adenoma of salivary gland: a potential role for MUC1 as a marker to predict recurrence. J Clin Pathol 2004; 57 (08) 813-821
  • 36 Tozoglu S, Hatipoglu M, Aytekin Z, Gurer EI. Extensive ameloblastic fibroma of the mandibula in a female adult patient: a case report with a follow-up of 3 years. Eur J Dent 2016; 10 (01) 139-143
  • 37 Gudi SS, Sikkerimath BC, Puranik RS, Kasbe SS. Swelling on lower lip…not always a mucocele!!!. Ann Maxillofac Surg 2013; 3 (01) 98-99
  • 38 Alcure ML, Della Coletta R, Graner E, Di Hipolito O. Jr Lopes MA. Sialolithiasis of minor salivary glands: a clinical and histopathological study. Gen Dent 2005; 53 (04) 278-281
  • 39 Sharma S, Mehendiratta M, Chaudhary N, Gupta V, Kohli M, Arora A. Squamous metaplasia in pleomorphic adenoma: a diagnostic and prognostic enigma. J Pathol Transl Med 2018; 52 (06) 411-415
  • 40 Kaveri H, Gopalkrishnana K, Venkatesh A. Cystic and florid squamous metaplasia in pleomorphic adenoma of palate - a diagnostic dilemma. Asian J Med Sci 2014; 5 (04) 108-110
  • 41 Takegawa K, Mitsumori K, Onodera H. et al. Induction of squamous cell carcinomas in the salivary glands of rats by potassium iodide. Jpn J Cancer Res 1998; 89 (02) 105-109