CC BY-NC-ND 4.0 · Journal of Digestive Endoscopy 2013; 04(02): 039-041
DOI: 10.1055/s-0039-1700270
Case Report
Society of Gastrointestinal Endoscopy of India

Mixed polyposis coli: Report of a rare entity with review of literature

Chalapathi Rao
Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh – 160012, India
,
Surinder Singh Rana
Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh – 160012, India
,
Manish Manrai
Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh – 160012, India
,
Vinita Chaudhary
Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh – 160012, India
,
Ritambhra Nada
1   Department of Histopathology Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh – 160012, India
,
Rajesh Gupta
2   Department of Surgery, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh – 160012, India
,
Kartar Singh
Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh – 160012, India
,
Deepak Kumar Bhasin
Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh – 160012, India
› Author Affiliations
Further Information

Publication History

Publication Date:
26 September 2019 (online)

ABSTRACT

Colorectal polyps may be detected incidentally on a screening colonoscopy or when they present with symptoms like anemia or gastrointestinal bleeding. Early recognition and prompt management of polyps can cure the primary disease and prevent future risk of malignancies in the patient and provide an opportunity to screen the families in cases of inherited polyposis syndromes. We report a case of rectal bleeding due to colorectal polyps of varying histology. Histology showed hyperplastic polyp, juvenile polyps (JP) with focal dysplasia, adenomatous polyp and villous adenoma with dysplasia. He underwent total proctocolectomy with ileal pouch anal anastomosis (J-pouch) (TP-IPAA). Mixed polyposis syndrome is a rare entity. (J Dig Endosc 2013;4(2):39-41)

 
  • References

  • 1 Itzkowitz SH, Potack J. Colonic Polyps and Polyposis Syndromes. In: Sleisenger and Fordtran’s Gastrointestinal and Liver Disease, 9th edn. Elsevier, Philadelphia, 2010; pp 2155-2188.
  • 2 P Rozen, Z Samuel, E Brazowski. A Prospective Study of the Clinical, Genetic, Screening, and Pathologic Features of a Family With Hereditary Mixed Polyposis Syndrome. Am J Gastroenterol 2003;98:2317–20.
  • 3 Monga G, Mazzucco G, Rossini FP, Presti F. Colorectal polyposis with mixed juvenile and adenomatous patterns. Virchows Arch 1979;382:355–60.
  • 4 Dodds WJ, Schulte WJ, Hensley GT, Hogan WJ. Peutz–Jeghers syndrome and gastrointestinal malignancy. Am J Roentgenol Radium Ther Nucl Med 1972;115:374–77.
  • 5 Longacre TA, Fenoglio-Preiser CM. Mixed hyperplastic adenomatous polyps/serrated adenomas: a distinct form of colorectal neoplasia. Am J Surg Pathol 1990;14:524–37.
  • 6 Murday V, Slack J. Inherited disorders associated with colorectal cancer. Cancer Surv 1989;8:139–57.
  • 7 Whitelaw SC, Murday VA, Tomlinson IPM, Thomas HJ, Cottrell S, Ginsberg A, et al. Clinical and molecular features of the hereditary mixed polyposis syndrome. Gastroenterology 1997;112:327–34.
  • 8 Jaeger EEM, Woodford-Richens KL, Lockett M, Rowan AJ, Sawyer EJ, Heinimann K, et al. An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome. Am J Hum Genet 2003;72:1261–7.
  • 9 Thomas H, Whitelaw S, Cottrell S, Murday VA, Tomlinson IP, Markie D, et al. Genetic mapping of hereditary mixed polyposis syndrome to chromosome 6q. Am J Hum Genet 1996; 58:770–76.
  • 10 Jaeger E, Leedham S, Lewis A, Segditsas S, Becker M, Cuadrado PR, et al. Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. Nat Genet 2012;44:699-703.
  • 11 Levin B, Lieberman DA, McFarland B, Andrews KS, Brooks D, Bond J, et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: A joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology 2008; 134:1570-95.