CC BY-NC-ND 4.0 · Indian J Plast Surg 2009; 42(S 01): S51-S55
DOI: 10.1055/s-0039-1699376
Review Article
Association of Plastic Surgeons of India

Syndromes and anomalies associated with cleft

R. Venkatesh
Department of Plastic Surgery, Sri Ramachandra University, Chennai, India
› Author Affiliations
Further Information

Publication History

Publication Date:
15 January 2020 (online)


Orofacial clefts are one of the commonest birth defects, and may be associated with other congenital anomalies. The majority of these orofacial clefts are nonsyndromic. A significant percentage of these clefts both syndromic and non-syndromic may have associated anomalies. Apart from reviewing other studies, this article also analyses a study of associated anomalies from a tertiary cleft centre in India.


  • 1 Leth Jensen B, Kreiborg S, Dahl E, Fogh-Andersen P. Cleft lip and palate in Denmark, 1976-1981: epidemiology, variability, and early somatic development. Cleft Palate 1988;25:258-69.
  • 2 Shprintzen RJ, Sigel-Sadewitz VL, Amato J, Goldberg RB. Anomalies associated with clefts lip, cleft palate, or both. Am J Med Gent 1985;20:585-95.
  • 3 Cohen MM Jr. Syndromes with Cleft lip and cleft palate. Cleft Palate J 1978;15:306-28.
  • 4 Winter RM, Baraister M. London dysmorpholgy Database, London neurogenetics database and Dysmorphology photo library on CD-ROM (version 3). Oxford: Oxford University press; 2001.
  • 5 Berge SJ, Plath H, Van de Vondel PT, Appel T, Niederhagen B, Von Lindern JJ, et al. Fetal cleft lip and palate: sonographic diagnosis, chromosomal abnormalities, associated anomalies and postnatal outcome in 70 fetuses. Ultrasound Obstet Gynecol 2001;18:422-31.
  • 6 Latham RA. The pathogenesis of cleft palate associated with the Pierre Robin syndrome. An analysis of a seventeen-week human foetus. Br J Plast Surg 1966;19:205-14.
  • 7 Tolorova MM, Cervenka J. Classification and birth prevalence of orofacial clefts. AM J med Genet 1998;75:126-37.
  • 8 Sullivan WG. Cleft lip with or with out cleft palate in blacks: An analysis of 81 patients. Plast Reconstr Surg 1989;84;406-8.
  • 9 Kromberg JG, Jenkins T. Common birth defects in South African Blacks. S Afr Med J 1982;62:599-602.
  • 10 Jensen BL, Kreiborg S, Dahl E, Fogh-Andersen P. Cleft lip and palate in Denmark, 1976-1981: epidemiology, variability, and early somatic development. Cleft Palate J 1988;25:258-69.
  • 11 Milerad J, Larson O, PhD D, Hagberg C, Ideberg M. associated malformations in infants with cleft lip and palate: a prospective, population-based study. Paediatrics 1997;100:180-6.
  • 12 Stoll C, Alembik Y, Dott B, Roth MP. Associated malformations in cases with oral clefts. Cleft Palate Craniofac J 2000;37:41-7.
  • 13 Zhou QJ, Shi B, Shi ZD, Zheng Q, Wang Y. Survey of the patients with cleft lip or palate in China who were funded for the surgery by the Smile Train program from 2000-2002. Chin Med J (Engl) 2006;119:1695-700.
  • 14 Rajabian MH, Sherkat M. An Epidemiologic study of Oral Clefts in Iran: an analysis of 1669 cases. Cleft Palate Craniofac J 2000;37:191-6.
  • 15 Cohen MM Jr. Syndromes with orofacial clefting. Cleft lip and palate: From origin to treatment. New York: Oxford University Press; 2002. p. 53-65.
  • 16 Hercilo M, Marcelo R, Mario SO, Roseli TM. Clinical and Genetic Features of Van der Woude Syndromes in Two large families in Brazil. Cleft Palate Craniofac J 2007;44:239-43.
  • 17 Pashayan MM, Lewis MB. Clinical experience with the Robin sequence. Cleft Palate J 1984;21:270-276.
  • 18 Robert J. Shprintzen:The Implications of the diagnosis of Robin sequence. Cleft Palate Craniofac J 1992;29:205-9.
  • 19 Thomas JA, Graham JM Jr. Chromosomes 22q11 deletion syndrome: an update for the primary peditrician. Clin Pediatr (Phila) 1997;36:253-66.
  • 20 Noordhoff MS, Huang CS, Lo LJ. Median facial dysplasia in unilateral and bilateral cleft lip and palate: a subgroup of median cerebrofacial malformations. Plast Reconstr Surg 1993;91:996-1005.