CC BY-NC-ND 4.0 · J Neuroanaesth Crit Care 2019; 06(03): 292-298
DOI: 10.1055/s-0039-1698609
Review Article
Indian Society of Neuroanaesthesiology and Critical Care

Cerebral Hyperperfusion Syndrome after Carotid Revascularization: A Brief Review

Saurabh Anand
1   Neuroanaesthesia and Neurocritical Care, Artemis Hospital, Gurugram, India
,
Asish K. Sahoo
1   Neuroanaesthesia and Neurocritical Care, Artemis Hospital, Gurugram, India
› Author Affiliations
Further Information

Publication History

received 01 August 2019

accepted after revision04 September 2019

Publication Date:
22 November 2019 (online)

Abstract

Cerebral hyperperfusion (CHS) syndrome is a relatively rare but potentially devastating event that can complicate carotid endarterectomy and carotid stenting. It is associated with increased cerebral perfusion usually more than 100% from the baseline along with ipsilateral headache, seizures, focal neurological deficits, encephalopathy, intracranial hemorrhage, or subarachnoid hemorrhage. Various risk factors have been identified but most important risk factor is preprocedure evidence of reduced cerebral vasoreactivity with or without contralateral severe carotid stenosis or occlusion. Although diagnosis is suspected in patients with clinical suspicion, it can be radiologically demonstrated with computed tomography (CT), magnetic resonance imaging (MRI), and by dynamic imaging of cerebral perfusion such as transcranial Doppler (TCD), CT, and MR perfusion, and single-photon emission computed tomography (SPECT). Management is usually centered around prompt recognition and active regulation of blood pressure in perioperative and postoperative periods to limit the rise of cerebral blood flow. Prognosis depends on the early detection and prompt management of CHS. If detected early, coupled with intensive blood pressure management, almost all patients will recover over a period of time. For those patients who are diagnosed late and those progressing to intracranial hemorrhage (ICH), the prognosis is not nearly as good.

 
  • References

  • 1 Yu S, Liebeskind DS, Dua S. et al. UCLA Stroke Investigators. Postischemic hyperperfusion on arterial spin labeled perfusion MRI is linked to hemorrhagic transformation in stroke. J Cereb Blood Flow Metab 2015; 35 (04) 630-637
  • 2 Zhang Y, Kumar A, Tezel JB, Zhou Y. Imaging evidence for cerebral hyperperfusion syndrome after intravenous tissue plasminogen activator for acute ischemic stroke. Case Rep Neurol Med 2016; 2016: 8725494
  • 3 van Mook WN, Rennenberg RJ, Schurink GW. et al. Cerebral hyperperfusion syndrome. Lancet Neurol 2005; 4 (12) 877-888
  • 4 Wang GJ, Beck AW, DeMartino RR, Goodney PP, Rockman CB, Fairman RM. Insight into the cerebral hyperperfusion syndrome following carotid endarterectomy from the national Vascular Quality Initiative. J Vasc Surg 2017; 65 (02) 381-389
  • 5 Spetzler RF, Wilson CB, Weinstein P, Mehdorn M, Townsend J, Telles D. Normal perfusion pressure breakthrough theory. Clin Neurosurg 1978; 25: 651-672
  • 6 Sundt Jr TM, Sharbrough FW, Piepgras DG, Kearns TP, Messick Jr JM, O’Fallon WM. Correlation of cerebral blood flow and electroencephalographic changes during carotid endarterectomy: with results of surgery and hemodynamics of cerebral ischemia. Mayo Clin Proc 1981; 56 (09) 533-543
  • 7 Kirchoff-Torres KF, Bakradze E. Cerebral hyperperfusion syndrome after carotid revascularization and acute ischemic stroke. Curr Pain Headache Rep 2018; 22 (04) 24
  • 8 Bouri S, Thapar A, Shalhoub J. et al. Hypertension and the post-carotid endarterectomy cerebral hyperperfusion syndrome. Eur J Vasc Endovasc Surg 2011; 41 (02) 229-237
  • 9 Moulakakis KG, Mylonas SN, Sfyroeras GS, Andrikopoulos V. Hyperperfusion syndrome after carotid revascularization. J Vasc Surg 2009; 49 (04) 1060-1068
  • 10 Bernstein M, Fleming JF, Deck JH. Cerebral hyperperfusion after carotid endarterectomy: a cause of cerebral hemorrhage. Neurosurgery 1984; 15 (01) 50-56
  • 11 Benzel EC, Hoppens KD. Factors associated with postoperative hypertension complicating carotid endarterectomy. Acta Neurochir (Wien) 1991; 112 (01) (02) 8-12
  • 12 Sakaki T, Tsujimoto S, Nishitani M, Ishida Y, Morimoto T. Perfusion pressure breakthrough threshold of cerebral autoregulation in the chronically ischemic brain: an experimental study in cats. J Neurosurg 1992; 76 (03) 478-485
  • 13 Skydell JL, Machleder HI, Baker JD, Busuttil RW, Moore WS. Incidence and mechanism of post-carotid endarterectomy hypertension. Arch Surg 1987; 122 (10) 1153-1155
  • 14 Farooq MU, Goshgarian C, Min J, Gorelick PB. Pathophysiology and management of reperfusion injury and hyperperfusion syndrome after carotid endarterectomy and carotid artery stenting. Exp Transl Stroke Med 2016; 8 (01) 7
  • 15 Cacheaux LP, Ivens S, David Y. et al. Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis. J Neurosci 2009; 29 (28) 8927-8935
  • 16 Janigro D, West GA, Nguyen TS, Winn HR. Regulation of blood-brain barrier endothelial cells by nitric oxide. Circ Res 1994; 75 (03) 528-538
  • 17 Holm J, Nilsson U, Waters N, Waters S, Jonsson O. Production of free radicals measured by spin trapping during operations for stenosis of the carotid artery. Eur J Surg 2001; 167 (01) 4-9
  • 18 Robertson D, Hollister AS, Biaggioni I. Netterville JL, Mosqueda-Garcia R, Robertson RM. The diagnosis and treatment of baroreflex failure. N Engl J Med 1993; 329 (20) 1449-1455
  • 19 Timmers HJLM, Wieling W, Karemaker JM, Lenders JWM. Baroreflex failure: a neglected type of secondary hypertension. Neth J Med 2004; 62 (05) 151-155
  • 20 Ogasawara K, Yukawa H, Kobayashi M. et al. Prediction and monitoring of cerebral hyperperfusion after carotid endarterectomy by using single-photon emission computerized tomography scanning. J Neurosurg 2003; 99 (03) 504-510
  • 21 Piepgras DG, Morgan MK, Sundt Jr TM, Yanagihara T, Mussman LM. Intracerebral hemorrhage after carotid endarterectomy. J Neurosurg 1988; 68 (04) 532-536
  • 22 Ogasawara K, Inoue T, Kobayashi M. et al. Cerebral hyperperfusion following carotid endarterectomy: diagnostic utility of intraoperative transcranial Doppler ultrasonography compared with single-photon emission computed tomography study. AJNR Am J Neuroradiol 2005; 26 (02) 252-257
  • 23 Abou-Chebl A, Reginelli J, Bajzer CT, Yadav JS. Intensive treatment of hypertension decreases the risk of hyperperfusion and intracerebral hemorrhage following carotid artery stenting. Catheter Cardiovasc Interv 2007; 69 (05) 690-696
  • 24 Buczek J, Karliński M, Kobayashi A, Białek P, Członkowska A. Hyperperfusion syndrome after carotid endarterectomy and carotid stenting. Cerebrovasc Dis 2013; 35 (06) 531-537
  • 25 Markus HS, Harrison MJ. Estimation of cerebrovascular reactivity using transcranial Doppler, including the use of breath-holding as the vasodilatory stimulus. Stroke 1992; 23 (05) 668-673
  • 26 Jansen C, Sprengers AM, Moll FL. et al. Prediction of intracerebral haemorrhage after carotid endarterectomy by clinical criteria and intraoperative transcranial Doppler monitoring: results of 233 operations. Eur. J Vasc Surg 1994; 8 (02) 220-225
  • 27 Yoshimoto T, Shirasaka T, Yoshizumi T, Fujimoto S, Kaneko S, Kashiwaba T. Evaluation of carotid distal pressure for prevention of hyperperfusion after carotid endarterectomy. Surg Neurol 2005; 63 (06) 554-557 discussion 557–558
  • 28 Hosoda K, Kawaguchi T, Ishii K. et al. Prediction of hyperperfusion after carotid endarterectomy by brain SPECT analysis with semiquantitative statistical mapping method. Stroke 2003; 34 (05) 1187-1193
  • 29 Sfyroeras GS, Karkos CD, Arsos G. et al. Cerebral hyperperfusion after carotid stenting: a transcranial Doppler and SPECT study. Vasc Endovasc Surg 2008; 00
  • 30 Karapanayiotides T, Meuli R, Devuyst G. et al. Postcarotid endarterectomy hyperperfusion or reperfusion syndrome. Stroke 2005; 36 (01) 21-26
  • 31 Ances BM, McGarvey ML, Abrahams JM. et al. Continuous arterial spin labeled perfusion magnetic resonance imaging in patients before and after carotid endarterectomy. J Neuroimaging 2004; 14 (02) 133-138
  • 32 Fukuda T, Ogasawara K, Kobayashi M. et al. Prediction of cerebral hyperperfusion after carotid endarterectomy using cerebral blood volume measured by perfusion-weighted MR imaging compared with single-photon emission CT. AJNR Am J Neuroradiol 2007; 28 (04) 737-742
  • 33 Nicholas GG, Hashemi H, Gee W, Reed III JF. The cerebral hyperperfusion syndrome: diagnostic value of ocular pneumoplethysmography. J Vasc Surg 1993; 17 (04) 690-695
  • 34 Fujimoto S, Toyoda K, Inoue T. et al. Diagnostic impact of transcranial color-coded real-time sonography with echo contrast agents for hyperperfusion syndrome after carotid endarterectomy. Stroke 2004; 35 (08) 1852-1856
  • 35 Pennekamp CW, Immink RV, den Ruijter HM. et al. Near-infrared spectroscopy can predict the onset of cerebral hyperperfusion syndrome after carotid endarterectomy. Cerebrovasc Dis 2012; 34 (04) 314-321
  • 36 Bozkurt MF, Saygi S, Erbas B. SPECT in a patient with postictal PLEDs: is hyperperfusion evidence of electrical seizure?. Clin Electroencephalogr 2002; 33 (04) 171-173
  • 37 Kernan WN, Ovbiagele B, Black HR. et al. American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Peripheral Vascular Disease. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2014; 45 (07) 2160-2236
  • 38 Giordano JM, Trout III HH. Kozloff L, DePalma RG. Timing of carotid artery endarterectomy after stroke. J Vasc Surg 1985; 2 (02) 250-255
  • 39 Kaisti KK, Langsjo JW, Aalto S. et al. Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiology 2003; 99 (03) 603-613
  • 40 Baharoglu MI, Cordonnier C, Salman RA. et al. PATCH Investigators. Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial. Lancet 2016; 387 (10038) 2605-2613
  • 41 Ogasawara K, Inoue T, Kobayashi M, Endo H, Fukuda T, Ogawa A. Pretreatment with the free radical scavenger edaravone prevents cerebral hyperperfusion after carotid endarterectomy. Neurosurgery 2004; 55 (05) 1060-1067
  • 42 Meyers PM, Higashida RT, Phatouros CC. et al. Cerebral hyperperfusion syndrome after percutaneous transluminal stenting of the craniocervical arteries. Neurosurgery 2000; 47 (02) 335-343, discussion 343–345
  • 43 Lieb M, Shah U, Hines GL. Cerebral hyperperfusion syndrome after carotid intervention: a review. Cardiol Rev 2012; 20 (02) 84-89