CC BY-NC-ND 4.0 · Semin Thromb Hemost 2020; 46(04): 398-409
DOI: 10.1055/s-0039-1697677
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

International Council for Standardization in Haematology Recommendations for Hemostasis Critical Values, Tests, and Reporting

Robert C. Gosselin
1   Thrombosis and Hemostasis Center, University of California, Davis Health System, Sacramento, California
Dorothy Adcock
2   Laboratory Corporation of America, Burlington, North Carolina
Akbar Dorgalaleh
3   Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
Emmanuel J. Favaloro
4   Department of Haematology, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research (ICPMR), NSW Health Pathology, Westmead Hospital, Westmead, New South Wales, Australia
Giuseppe Lippi
5   Dipartimento di Scienze Neurologiche e del Movimento, Sezione di Biochimica Clinica, Universita degli Studi di Verona, Verona, Italy
João M. Pego
6   Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Irene Regan
7   Coagulation Department, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland
Virginie Siguret
8   Service d'hématologie Biologique, Hôpital Lariboisière, Université Paris Descartes, Paris, France
› Author Affiliations
Further Information

Publication History

Publication Date:
22 October 2019 (online)


This guidance document was prepared on behalf of the International Council for Standardization in Haematology (ICSH), the aim of which is to provide hemostasis-related guidance documents for clinical laboratories. The current ICSH document was developed by an ad hoc committee, comprising an international collection of both clinical and laboratory experts. The purpose of this ICSH document is to provide laboratory guidance for (1) identifying hemostasis (coagulation) tests that have potential patient risk based on analysis, test result, and patient presentations, (2) critical result thresholds, (3) acceptable reporting and documenting mechanisms, and (4) developing laboratory policies. The basis for these recommendations was derived from published data, expert opinion, and good laboratory practice. The committee realizes that regional and local regulations, institutional stakeholders (e.g., physicians, laboratory personnel, hospital managers), and patient types (e.g., adults, pediatric, surgical) will be additional confounders for a given laboratory in generating a critical test list, critical value thresholds, and policy. Nevertheless, we expect this guidance document will be helpful as a framework for local practice.