CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2019; 54(06): 692-696
DOI: 10.1055/s-0039-1697019
Artigo Original
Sociedade Brasileira de Ortopedia e Traumatologia. Published by Thieme Revnter Publicações Ltda Rio de Janeiro, Brazil

Oral Administrations of Hancornia speciosa Gomes Latex Do Not Increase Bone Neoformation[*]

Article in several languages: português | English
1  Departamento de Morfologia, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, SP, Brasil
,
Rafaela Mariano Bereta
2  Departamento de Saúde Bucal, Escola Técnica Qualificar, Florianópolis, SC, Brasil
,
Sônia Maria Stefano Piedade
3  Departamento de Ciências Exatas, Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, Piracicaba, SP, Brasil
,
Pedro Duarte Novaes
1  Departamento de Morfologia, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, SP, Brasil
› Author Affiliations
Further Information

Publication History

04 June 2018

08 August 2018

Publication Date:
25 September 2019 (online)

Abstract

Objective The present work aimed to evaluate the systemic effect of H. speciosa latex on bone neoformation.

Methods For this, the latex was collected and diluted to 3% and 50%. A total of 28 Wistar rats were submitted to surgery to create a 5 mm diameter defect in the parietal bone. This experiment was conducted in 2 different periods: 1 and 2. For each period, the rats were divided into 3 groups: Control Group, Latex3 Group, and Latex50 Group, which received, respectively, daily administrations of 0.5 mL of distilled water, latex to 3% and latex to 50% by gavage, orally. The rats of periods 1 and 2 were euthanized, respectively, 15 and 30 days after the surgery, and the calvaria was collected. The results were analyzed using the ANOVA and Tukey tests; the significance level was 0.05.

Results We show that, in each analyzed period, the experimental groups had the same amount of newly formed bone in the calvaria defect.

Conclusion We conclude that daily and oral administrations of H. speciosa latex to 3% and to 50% over a period of 15 and 30 days does not contribute to the increase of the area of the newly formed bone in the calvaria defect.

* Study developed at the Department of Morphology, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, SP, Brazil.