Delayed Cerebral Metastasis of Breast Cancer: Case Report and Molecular Review

Abstract

Breast cancer (BC) is a prevalent disease, and its incidence of brain metastasis (BM) varies from 5 to 30% according to the literature. We present the case of a delayed isolated cerebral metastasis in a female patient following a period of 16 years after the diagnosis and first treatment. During this time, there was no other recurrence. We also review the literature concerning central nervous system spread and the molecular subtypes of such late tumors.

Resumo

O câncer de mama é uma doença prevalente e sua incidência de metástase cerebral varia de 5 a 30%, de acordo com a literatura. Apresentamos um caso de metástase cerebral tardia isolada em uma paciente do sexo feminino após um período de 16 anos do diagnóstico e tratamento. Durante esse período, não houve outra recorrência. Também é feita uma breve revisão da literatura sobre metástases de câncer de mama no sistema nervoso central e suas características moleculares.

Keywords

breast cancer - neuro-oncology - delayed metastasis

Palavras-chave

câncer de mama - neuro-oncologia - metástase tardia

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