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Semin intervent Radiol 2019; 36(03): 213-220
DOI: 10.1055/s-0039-1693980
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Irreversible Electroporation of the Pancreas

Authors

  • Gabriel Chan

    1   Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore

  • Uei Pua

    1   Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore
    2   Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Further Information

Publication History

Publication Date:
19 August 2019 (online)

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Abstract

Irreversible electroporation (IRE) is a relatively recent method of ablation. In contrast to many ablation devices that use thermal methods to induce cell death, IRE employs the use of an electric field to cause irreversible permeability of the cell membrane, thus inducing apoptosis. Since its use in the pancreas was first described in 2012, IRE has become established as part of the armamentarium of ablation devices currently available. The crucial advantage of IRE compared with other devices employing thermal ablation is the safety around vital structures such as vessels and ducts. This is especially important in the pancreas due to the close proximity of multiple major vascular structures, biliary ducts, and adjacent gastrointestinal organs. This article will explore the current evidence regarding the use of IRE in the pancreas.

Keywords

interventional radiology - pancreas - ablation - irreversible electroporation