CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2020; 55(02): 131-138
DOI: 10.1055/s-0039-1692626
Artigo de Revisão
Coluna
Sociedade Brasileira de Ortopedia e Traumatologia. Published by Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Genetic Influence in Disc Degeneration - Systematic Review of Literature[*]

Article in several languages: português | English
Ricardo Vieira Teles Filho
1  Departamento de Ortopedia e Traumatologia, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, GO, Brasil
,
Guilherme de Matos Abe
1  Departamento de Ortopedia e Traumatologia, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, GO, Brasil
,
1  Departamento de Ortopedia e Traumatologia, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, GO, Brasil
2  Centro de Reabilitação e Readaptação Dr Henrique Santillo, Goiânia, GO, Brasil
› Author Affiliations
Further Information

Publication History

22 February 2018

02 July 2018

Publication Date:
27 August 2019 (online)

Abstract

Disc degeneration is a condition that compromises the intervertebral disc functions, which can lead to several important pathological processes, such as disc herniation and canal stenosis. Although its etiology is still unknown, more and more studies have demonstrated the preponderant role of genetic factors to the detriment of environmental factors. Aiming to review the current knowledge about the genes associated with intervertebral disc degeneration, we have performed a narrative review based on the medical literature in the English language from the last 10 years regarding this subject. We have concluded that several genes have been associated with disc degeneration in humans, including the genes for collagen I α-1 (COL1A1), collagen IX (COL9A2 and COL9A3), collagen XI (COL11A2), interleukin 6 (IL-6), aggrecan (AGC1), vitamin D receptor (VDR), and matrix metalloproteinase 3 (MMP-3), in addition to microRNAs. Therefore, the present review emphasizes the latest advancements in the association of genes with specific phenotypes of degenerated discs, single-nucleotide polymorphisms, heritage and genetic-environmental interactions in relation to disc degeneration to help future reviews regarding the genetic mechanisms underlying these processes.

* Work performed by the Spine Group of Rehabilitation and Readaptation Center Dr. Henrique Santillo (CRER) and Faculdade de Medicina from Universidade Federal de Goiás (FM/UFG), Goiânia, GO, Brazil.