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Randomized, Controlled, Prospective Clinical Trial of the Effects of Autologous Greater Omentum Free Graft versus No Graft in Dogs Treated with TPLO for Cranial Cruciate Ligament Rupture
07 August 2019 (online)
Introduction: The primary objective of this pilot study was to determine the rate of radiographic healing of TPLO osteotomies and owner reported outcome in dogs with naturally occurring cranial cruciate ligament rupture (CCLR) treated with (OG) or without (NG) a free autogenous omental graft.
Materials and Methods: Eight dogs were prospectively randomized to receive either OG or NG at arthroscopy and TPLO for unilateral CCLR. Radiographs, visual analog scale and owner questionnaire (CBPI and COI) were performed at 6, 8, 10 and 12 weeks postoperative. Radiographs were assessed by a blinded board eligible radiologist using an 11- and a 5-point healing scale.
Results: Five point and 11-point healing scores for OG (2.6 ± 0.4, mean ± SE, 5.2 ± 0.9) trended higher than for NG (1.3 ± 0.3, 2.3 ± 1.5, p > 0.05). No difference in visual analog scale or owner assessments was found (p > 0.05).
Discussion/Conclusion: OG in the TPLO osteotomy site does not affect owner assessment of outcome but may reduce the amount of time for bone healing to occur at the osteotomy site. Further investigation in larger numbers of dogs is warranted to determine the effects of OG on TPLO osteotomy site healing compared with no augmentation in dogs.
Acknowledgment: There was no proprietary interest or funding provided for this project