CC BY 4.0 · Synlett 2020; 31(13): 1244-1258
DOI: 10.1055/s-0039-1690904
account
This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/) (2020) The Author(s)

The Problem with Problems: Fundamental to Applied Research Using Palladium

The studies are very grateful for the support we have received from the following sources for the chemistry described in this Account: EPSRC (EP/R025754/1), The Leverhulme Trust (RPG-2015-308), and GlaxoSmithKline and AstraZeneca for several CASE awards and iCASE studentships.
Further Information

Publication History

Received: 18 February 2020

Accepted after revision: 01 April 2020

Publication Date:
05 May 2020 (online)


Dedicated to our co-workers and collaborators, past, present, and future

Abstract

This Account describes the development of our cross-coupling and medicinal chemistry research from its origins at the outset of my independent career through to the present day. Throughout, the decisions and motivations as well as the mistakes and pitfalls are discussed.

1 Introduction

2 Hobbies and Interests

3 Scooped before Starting

4 Opportunity from Collaboration

5 Chemoselective Suzuki–Miyaura Cross-Coupling

6 Applications to the Medicinal Chemistry Campaign

7 Autotaxin and Heterocycle Synthesis

8 ATX Hybrids and Pd(II) Speciation

9 Conclusions

 
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