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Synthesis 2020; 52(03): 450-458
DOI: 10.1055/s-0039-1690238
DOI: 10.1055/s-0039-1690238
paper
Synthesis of N-(Hetero)arylconvolvine Derivatives through a Palladium-Catalyzed Buchwald–Hartwig Cross-Coupling
Authors acknowledge support of this project by CNRS, University Paris Sud, and by La Ligue Nationale Contre le Cancer throughout an Equipe Labellisée 2014 grant. The authors are grateful to the Ministry of Higher Education and Scientific Research of Tunisia for financial support. Our laboratory (BioCIS UMR 8076) is a member of the laboratory of excellence LERMIT supported by a grant from ANR (ANR-10-LABX-33).Weitere Informationen
Publikationsverlauf
Received: 02. Oktober 2019
Accepted after revision: 14. Oktober 2019
Publikationsdatum:
05. November 2019 (online)
Abstract
The present study describes the isolation of convolvine from the roots of the Tunisian plant Convolvulus dorycnium L. and its synthesis through a four-step sequence starting from tropine. Then, an efficient synthesis of N-(het)aryltropanes derivatives by a sequence of a palladium-catalyzed N-arylationof convolvine has been established. This strategy enabled access to unknown tropane scaffolds of biological interests.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690238.
- Supporting Information
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