Synthesis 2020; 52(04): 529-536
DOI: 10.1055/s-0039-1690014
paper
© Georg Thieme Verlag Stuttgart · New York

Allylic C–H Alkynylation via Copper-Photocatalyzed Cross-Dehydrogenative Coupling

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Leibniz Institute for Catalysis, Albert-Einstein-Str. 29a, 18059 Rostock, Germany   Email: Esteban.Mejia@catalysis.de
› Author Affiliations
Financial support by the German Academic Exchange Service, DAAD (Leadership for Syria Program) is gratefully acknowledged.
Further Information

Publication History

Received: 30 April 2019

Accepted after revision: 18 July 2019

Publication Date:
25 July 2019 (online)


Published as part of the Bürgenstock Special Section 2019 Future Stars in Organic Chemistry

Abstract

An efficient, novel photocatalyzed allylic-alkynylation methodology via copper-based cross-dehydrogenative coupling (CDC) is described. Different types of 1,4-enyne compounds were synthesized in one step at room temperature using copper(I) terpyridyl complex as photocatalyst/initiator. This procedure is an improvement and to some extent complementary to previously reported thermal CDC methods. Preliminary investigations on the reaction mechanism are also presented.

Supporting Information

 
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