Thromb Haemost 2019; 119(08): 1373-1378
DOI: 10.1055/s-0039-1688829
Stroke, Systemic or Venous Thromboembolism
Georg Thieme Verlag KG Stuttgart · New York

Clinical Characteristics of Patients with a Right Ventricular Thrombus in Arrhythmogenic Right Ventricular Cardiomyopathy

Deniz Akdis*
1  University Heart Center Zurich, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
,
Kai Chen*
2  Fuwai Hospital, Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, Beijing, China
,
Ardan M. Saguner
1  University Heart Center Zurich, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
,
Simon F. Stämpfli
1  University Heart Center Zurich, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
,
Xiao Chen
2  Fuwai Hospital, Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, Beijing, China
,
Liang Chen
2  Fuwai Hospital, Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, Beijing, China
,
Man Rao
2  Fuwai Hospital, Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, Beijing, China
,
Laurent M. Haegeli
1  University Heart Center Zurich, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
,
Felix C. Tanner
1  University Heart Center Zurich, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
,
Corinna Brunckhorst
1  University Heart Center Zurich, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
,
Jiangping Song*
2  Fuwai Hospital, Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, Beijing, China
,
Firat Duru*
1  University Heart Center Zurich, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
3  Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
› Author Affiliations
Funding The Zurich ARVC Program is supported from funds from Schwyzer Foundation and Baugarten Foundation in Zurich, Wild Foundation in Zug, as well as from research grants from the Swiss National Foundation. The Beijing ARVC Program is supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2016-I2M-1-015) and the National Center for Cardiovascular Research.
Further Information

Publication History

26 November 2018

29 March 2019

Publication Date:
10 June 2019 (eFirst)

Abstract

Background Thrombus formation within the left ventricle (LV) is a well-known clinical entity and is often associated with underlying myocardial disease, whereas right ventricular (RV) thrombi are rarely observed. This study aimed to investigate the clinical characteristics of patients with arrhythmogenic RV cardiomyopathy (ARVC) who developed an RV thrombus.

Methods and Results This study included patients with an RV thrombus from the ARVC databases of the University Heart Center in Zurich, Switzerland, and the Fuwai Hospital in Beijing, China. In total, there were 13 ARVC patients who had an RV thrombus detected. The mean age was 33 ± 15 (range: 11–51) years. Eight patients (62%) were male. The mean Task Force score was 6 ± 1. Nine of these patients (69%) had an RV thrombus only whereas four patients had biventricular thrombi. All 13 ARVC patients had a severely impaired RV function (RV fractional area change 16 ± 9% and RV ejection fraction 15 ± 4%); LV ejection fraction (LVEF) was 40 ± 15%. ARVC patients with an additional LV thrombus had a lower LVEF than the others (24 ± 11 vs. 47 ± 11, p = 0.02). Under therapeutic anticoagulation, complete thrombus resolution was observed in 9/13 patients (69%).

Conclusion RV thrombus formation is a potential complication of ARVC with impaired RV function. In patients with biventricular involvement, thrombi may also occur within the LV. Anticoagulation is generally effective to dissolve RV thrombi. This study highlights the need for awareness during cardiac imaging to detect this rare complication of ARVC.

* Deniz Akdis and Kai Chen are shared first authors.


** Firat Duru and Jiangping Song are senior co-authors.