Competing Endogenous RNAs in Hepatocellular Carcinoma—The Pinnacle of Rivalry

Abdelrahman Yousry Afify; Salma Abdulmaqsoud Ibrahim; Mennah Hisham Aldamsisi; Mai Saad Zaghloul; Nada El-Ekiaby; Ahmed Ihab Abdelaziz

doi:10.1055/s-0039-1688442

Seminars in Liver Disease, Inhaltsverzeichnis

Semin Liver Dis 2019; 39(04): 463-475
DOI: 10.1055/s-0039-1688442

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Competing Endogenous RNAs in Hepatocellular Carcinoma—The Pinnacle of Rivalry

Abdelrahman Yousry Afify

¹School of Medicine, Newgiza University (NGU), Giza, Egypt

,

Salma Abdulmaqsoud Ibrahim

¹School of Medicine, Newgiza University (NGU), Giza, Egypt

,

Mennah Hisham Aldamsisi

¹School of Medicine, Newgiza University (NGU), Giza, Egypt

,

Mai Saad Zaghloul

¹School of Medicine, Newgiza University (NGU), Giza, Egypt

,

Nada El-Ekiaby

¹School of Medicine, Newgiza University (NGU), Giza, Egypt

,

Ahmed Ihab Abdelaziz

¹School of Medicine, Newgiza University (NGU), Giza, Egypt

› Institutsangaben

Abstract

The role of noncoding transcripts in gene expression is nowadays acknowledged to keep various diseases at bay—despite being referred to as “junk” DNA several years ago. Believed to be at the heart of multiple regulatory pathways, microRNAs (miRNAs) are small noncoding RNAs (ncRNAs) involved in posttranscriptional gene regulation. Recently, the discovery of ncRNAs that compete for shared miRNA pools has dimmed the light on the solo performance of miRNAs in genomic regulation. Indeed, several studies describe RNAs such as long noncoding RNAs, mRNAs, circular RNAs, pseudogenes, and viral RNAs as competing endogenous RNAs (ceRNAs) that sequester miRNAs, allowing for de-repression of downstream miRNA targets. Such integration between coding and noncoding transcripts forms complex ceRNA networks that when dysregulated lead to several diseases such as hepatocellular carcinoma. Here, the authors review perturbed ceRNA networks in hepatocellular carcinoma, describe the role of each in tumorigenesis, and discuss their various clinical implications.

Keywords

competing endogenous RNAs - microRNAs - hepatocellular carcinoma

Volltext

Referenzen

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