Diabetologie und Stoffwechsel 2019; 14(S 01): S25
DOI: 10.1055/s-0039-1688178
Freie Vorträge
Epidemiologie und Versorgungsforschung
Georg Thieme Verlag KG Stuttgart · New York

Inverse associations between serum afamin concentrations and inflammatory biomarkers in an older adult population: Results from KORA F4 study

Authors

  • H Maalmi

    1   German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany;, Institute for Clinical Diabetology, Düsseldorf, Germany

  • T Fischer

    1   German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany;, Institute for Clinical Diabetology, Düsseldorf, Germany

  • F Kronenberg

    2   Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria, Division of Genetic Epidemiology, Innsbruck, Austria

  • B Thorand

    3   German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Helmholtz Zentrum, Neuherberg, Germany, Institute of Epidemiology, Neuherberg, Germany

  • W Rathmann

    4   German Center for Diabetes Research (DZD), München-Neuherberg, Germany; German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany, Institute for Biometrics and Epidemiology, Düsseldorf, Germany

  • M Heier

    5   Helmholtz Zentrum, Neuherberg, Germany, Institute of Epidemiology, Neuherberg, Germany

  • A Peters

    3   German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Helmholtz Zentrum, Neuherberg, Germany, Institute of Epidemiology, Neuherberg, Germany

  • W Koenig

    6   University of Ulm, Ulm, Germany; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany, Institute of Epidemiology and Medical Biometry, Ulm, Germany

  • M Roden

    1   German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany;, Institute for Clinical Diabetology, Düsseldorf, Germany

  • C Herder

    1   German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany;, Institute for Clinical Diabetology, Düsseldorf, Germany

  • M Carstensen-Kirberg

    1   German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany;, Institute for Clinical Diabetology, Düsseldorf, Germany
Further Information

Publication History

Publication Date:
07 May 2019 (online)

Also available at
 

Background:

A meta-analysis of eight cohorts reported an association between higher concentrations of afamin, a vitamin E-binding glycoprotein, and the incidence of type 2 diabetes (T2D). This association may be partially explained by inflammation. However, while the association between inflammation and T2D is well investigated, the association between inflammation and afamin remains unclear. Therefore, we hypothesized that afamin might be positively associated with pro- and inversely related to anti-inflammatory biomarkers implicated in T2D.

Methods:

This cross-sectional study included 1,041 participants aged 62 – 81 years from the KORA F4 study, of whom 622 had prediabetes or T2D. Serum concentrations of afamin as well as pro-inflammatory [high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), IL-18 and tumor necrosis factor alpha (TNF-α)] and anti-inflammatory [adiponectin, IL-22 and IL-1 receptor alpha (IL-1Rα)] biomarkers were measured using a high-sensitivity latex-enhanced nephelometric assay (hsCRP) or ELISA (all others). Associations between inflammatory biomarkers and afamin (dependent variable) were evaluated using multiple linear regressions.

Results:

Serum afamin concentrations were inversely associated with serum concentrations of both pro-inflammatory biomarkers [CRP: β=-1.1 (–1.9; –0.4), p = 0.0025; IL-6: β=-1.9 (–3.0; –0.7), p = 0.0016] and anti-inflammatory biomarkers [adiponectin: β=-3.2 (–4.5; –1.9), p < 0.0001); IL-22: β=-0.8 (–1.4; –0.1), p = 0.0249] after adjustment for age, sex, BMI and multiple metabolic and lifestyle factors. No associations with afamin were found for IL-18, TNF-α and IL-1Rα.

Conclusion:

Serum afamin concentrations are inversely associated with both pro- and anti-inflammatory biomarkers. Mechanistic studies should clarify whether inflammatory biomarkers are involved in the association between afamin and T2D.