Thromb Haemost 2019; 119(07): 1194-1197
DOI: 10.1055/s-0039-1687880
Letter to the Editor
Georg Thieme Verlag KG Stuttgart · New York

The Procoagulant Profile in Patients with Immune Thrombocytopenia and Its Association with Bleeding Symptoms

1  Research Collaborations in Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
,
Benjaporn Akkawat
1  Research Collaborations in Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
,
Ponlapat Rojnuckarin
1  Research Collaborations in Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
› Author Affiliations
Funding This study was supported by the Thai Society of Hematology.
Further Information

Publication History

09 October 2018

14 March 2019

Publication Date:
30 April 2019 (eFirst)

Introduction

Immune thrombocytopenia (ITP) is characterized by isolated thrombocytopenia with increased risks of bleeding.[1] Although severe thrombocytopenia is an important predictor of major bleeding,[2] bleeding severity inconsistently correlates with platelet count. Several factors have been shown to be associated with bleeding severity in ITP patients. These include platelet activation markers,[3] immature platelet fraction, and thromboelastometry.[4] The varying degrees of plasma thrombin generation may explain the bleeding heterogeneity found in ITP population. Thrombin generation test (TGT) has been reported to predict bleeding in certain bleeding disorders[5] [6] [7] and surgery.[8] This study aims to explore the TGT variables in primary ITP patients compared with healthy controls and their associations with bleeding symptoms.