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Clin Colon Rectal Surg 2019; 32(05): 386-393
DOI: 10.1055/s-0039-1687835
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Premalignant and Malignant Perianal Lesions

Mohammad Ali Abbass
1   Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio
,
Michael A. Valente
1   Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio
› Author Affiliations
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Publication History

Publication Date:
22 August 2019 (online)

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Abstract

Anal cancer is a heterogeneous and rare disease process that accounts for ∼1.5% of all gastrointestinal tract malignancies. The perianal skin plays host to a variety of different premalignant and malignant lesions, all with variable histology, treatment options, and prognosis. Anal cancers in general are notorious for having a delayed or missed diagnosis leading to treatment delays and may have an impact on survival. This delay is in part due to the nonspecific symptomatology and also improper physical examination of the sensitive and anatomically complex perianal region and anal canal. This article examines the various types of perianal cancers and their precursor lesions and will explore treatment options as well as outcomes and prognosis.

Keywords

perianal cancers - squamous cell carcinoma - basal cell carcinoma - extramammary Paget's disease - anal adenocarcinoma - Buschke–Löwenstein tumor - verrucous carcinoma - mycosis fungoides
 

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