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Thromb Haemost 1979; 42(01): 329
DOI: 10.1055/s-0039-1687310
Platelet Kinetics: Clinical
Poster board
Schattauer GmbH

Plasma Concentrations of Platelet Specific Proteins Correlated with Platelet Survival

D.J. Doyle
1   Department of Medicine, University of Melbourne, and St. Vincent’s School of Medical Research, St. Vincent’s Hospital, and Intensive Care Unit, Royal Melbourne Hospital, Melbourne, Australia
1   Department of Medicine, University of Melbourne, and St. Vincent’s School of Medical Research, St. Vincent’s Hospital, and Intensive Care Unit, Royal Melbourne Hospital, Melbourne, Australia
,
C.N. Chesterman
1   Department of Medicine, University of Melbourne, and St. Vincent’s School of Medical Research, St. Vincent’s Hospital, and Intensive Care Unit, Royal Melbourne Hospital, Melbourne, Australia
,
J.F. Cade
1   Department of Medicine, University of Melbourne, and St. Vincent’s School of Medical Research, St. Vincent’s Hospital, and Intensive Care Unit, Royal Melbourne Hospital, Melbourne, Australia
,
F.J. Morgan
1   Department of Medicine, University of Melbourne, and St. Vincent’s School of Medical Research, St. Vincent’s Hospital, and Intensive Care Unit, Royal Melbourne Hospital, Melbourne, Australia
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Publication Date:
26 April 2019 (online)

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Relationships between platelet survival (51Cr) and plasma concentrations (radioimmunoassay) of β-thromboglobulin (βTC) and platelet factor 4 (PF4) were analysed in 91 studies of patients prior to and after coronary artery bypass surgery. Platelet lifespans were calculated using the linear, exponential, weighted mean (WM) and multiple hit (MH) models. The values obtained approximated normal distributions and all the indices correlated, r values ranging from 0.69 to 6 (p<0,001 in all cases).

βTC had significant negative correlations with all indices of platelet survival, the most significant being with MH (r = -0.39, p<0.001). Of interest was the correlation of βTG with the number of hits (n) in MH (r = -0.29, p<0.01). PF4 correlated with all indices of platelet survival except n, the most significant correlation was with WM (r = 0.33, p<0.01). BTC and PF4 were highly correlated (r = 0.62, p<0.001), however no benefit was obtained by combining measurements of the two proteins in any regression with platelet lifespan.

The results suggest that shortened platelet survival in vascular disease is associated with platelet release of BTG and PF4 and that these platelet specific proteins are comparable as markers of platelet activation in vivo.