Semin Liver Dis
DOI: 10.1055/s-0039-1685524
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Lipid Droplet Formation and Lipophagy in Fatty Liver Disease

Ryan J. Schulze
1  Department of Biochemistry and Molecular Biology and the Center for Digestive Diseases, Mayo Clinic, Rochester, Minnesota
,
Mark A. McNiven
1  Department of Biochemistry and Molecular Biology and the Center for Digestive Diseases, Mayo Clinic, Rochester, Minnesota
› Author Affiliations
Further Information

Publication History

Publication Date:
30 April 2019 (eFirst)

Abstract

Lipid droplets (LDs) are key sites of neutral lipid storage that can be found in all cells. Metabolic imbalances between the synthesis and degradation of LDs can result in the accumulation of significant amounts of lipid deposition, a characteristic feature of hepatocytes in patients with fatty liver disease, a leading indication for liver transplant in the United States. In this review, the authors highlight new literature related to the synthesis and autophagic catabolism of LDs, discussing key proteins and machinery involved in these processes. They also discuss recent findings that have revealed novel genetic risk factors associated with LD biology that contribute to lipid retention in the diseased liver.