Importance of Temperament in Individualized Homeopathic Prescription: Evaluation by an Open, Randomized, Pilot TrialFunding We received no funding for the project. The cost of the project was borne by the authors themselves. The institutional pharmacy supplied the medicines used in the project, but the institution had no role to play in the conduct of the study and publication of the manuscript.
18 December 2018
21 February 2019
17 May 2019 (eFirst)
Background The importance of temperament in the selection of an individualized homeopathic medicine has not been evaluated systematically. The current study explored this under-researched area.
Materials and Methods A prospective, open, randomized (1:1), two parallel arms, pilot trial was performed on patients suffering from various chronic diseases. Each patient's temperament was assessed using a newly developed “temperament diagnostic questionnaire”. Outcome measures were health status using the EQ-5D-5L questionnaire and a visual analog scale (VAS) of patient's self-rated health, measured at baseline and at 3 months. Homeopathic medicines were prescribed on the basis of individualization, randomly with or without accounting for individual temperament, and patients grouped accordingly (temperament(+) and temperament(−)). Baseline comparability of the two groups was checked, followed by analysis of group differences. A p-value < 0.01 was considered as statistically significant.
Results Fifty protocol-compliant patients were analyzed. The two groups were comparable at baseline. Over 3 months of intervention, there was significant improvement (p < 0.01) in each group. Though improvement in the EQ-5D-5L score was greater in the temperament(+) group (mean difference, 2.4; 95% confidence interval [CI], 0.2 to 4.5), the change did not achieve the threshold for statistical significance (p = 0.029). Improvement in VAS score was significantly greater in the temperament(+) group than in temperament(–) patients (mean difference, 15.2; 95% CI, 4.9 to 25.4; p = 0.004).
Conclusion Considering temperament as a key element of individualized prescription may enhance health improvement from homeopathic treatment in chronic diseases. Independently replicated rigorous trials with validated scales are warranted.
Trial Registration CTRI/2018/03/012433.
• A prospective, open, randomized (1:1), two parallel arms, pilot trial was performed on patients suffering from various chronic diseases.
• Patients were randomized to either temperament(+) or temperament(−) prescription groups.
• Outcome measures were EQ-5D-5L Bengali questionnaire and visual analog scale (VAS), measured at baseline and after 3 months.
• Medicines were prescribed on the basis of individualization ± temperament.
• Over 3 months of intervention, there was significant improvement in both groups, but improvement was higher in the temperament(+) prescription group than the other.
• Considering temperament as one of the key elements of individualized homeopathic prescription produced promising benefits.
NS: Conceptualization; data curation; investigation; methodology; project administration; resources; review and editing.
AS: Conceptualization; data curation; project administration; supervision.
MK: Formal analysis; software; validation; roles/writing—original draft; writing—review & editing.
SS: Conceptualization; methodology; formal analysis; software; validation; roles/writing—original draft; writing—review & editing.
- 1 Sertima IV. The Golden Age of the Moor. New Brunswick: Transaction Publisher; 1992: 17
- 2 Sudhoff K. Essays in the History of Medicine. New York: Medical Life Press; 1926: 67 , 87, 104
- 3 Merenda PF. Toward a four-factor theory of temperament and/or personality. J Pers Assess 1987; 51: 367-374
- 4 Naseri M, Rezaeizadeh H, Taheripanah T, Naseri V. Temperament theory in the Iranian Traditional Medicine and variation in therapeutic responsiveness based on pharmacogenetics. J Islam Iran Tradit Med. 2010; 1: 237-242
- 5 Hahnemann S. Organon of Medicine, 5th and 6th eds. New Delhi: B. Jain Publishers (P) Ltd.; 2002
- 6 Hering C. Mind and disposition. 2nd ed. In: Analytical Repertory of the Symptoms of the Mind. New Delhi: B. Jain Publishers (P) Ltd; 2006: 69
- 7 Von Boenninghausen CMF. The Lesser Writings. Reprint ed. New Delhi: B. Jain Publishers (P) Ltd.; 2000: 107 , 298
- 8 Boger CM. Boenninghausen's Characteristics and Repertory with Corrected Abbreviations and Word Index. Reprint ed. New Delhi: B. Jain Publishers (P) Ltd.; 2012: viii
- 9 Kent JT. New Remedies, Clinical Cases, Lesser Writings, Aphorisms and Precepts. Reprint ed. New Delhi: B. Jain Publishers (P) Ltd.; 2002: 337-377
- 10 Robert HA. The Principles and Art of Cure by Homoeopathy. Reprint ed. New Delhi: B. Jain Publishers (P) Ltd.; 2007: 169-173
- 11 Knerr CB. Repertory of Hering's Guiding Symptoms of Our Materia Medica. Reprinted. New Delhi: B Jain Publishers (P) Ltd.; 1980
- 12 Clarke JH. A Clinical Repertory to the Dictionary of Materia medica. 9th impression, New Delhi: B. Jain Publishers (P) Ltd.; 2015
- 13 Murphy R. Homoeopathic Medical Repertory. 2nd ed, New Delhi: B. Jain Publishers (P) Ltd.; 2002
- 14 Schroyens F. Synthesis. Repertorium Homoeopathicum Syntheticum. 9.1 ed. New Delhi: B Jain Publishers (P) Ltd.; 2014
- 15 Zandvoort R. The Complete Repertory. 1st ed. Leidschendam: IRHIS Publishers; 1996
- 16 Mojahedi M, Naseri M, Majdzadeh R. , et al. Reliability and validity assessment of Mizaj questionnaire: a novel self-report scale in Iranian Traditional Medicine. Iran Red Crescent Med J 2014; 16: e15924
- 17 Roshandel HRS, Ghadimi F, Roshandel RS. Developing and standardization of a structured questionnaire to determine the temperament (Mizaj) of individuals. Indian J Tradit Knowl 2016; 15: 341-346
- 18 Okal BO. The functionality of four temperaments and communication theories towards the realization of peaceful general elections in Kenya. J Sociol Res 2012; 3: 55-66
- 19 The Euro-QOL group. EQ-5D–5L 2015 . Available at: http://www.euroqol.org/eq-5d-products/eq-5d-5l.html . Accessed July 18, 2016
- 20 EuroQol Group. EuroQol—a new facility for the measurement of health-related quality of life. Health Policy 1990; 16: 199-208
- 21 Herdman M, Gudex C, Lloyd A. , et al. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual Life Res 2011; 20: 1727-1736
- 22 Cleophas TJ. Clinical trials and p-values, beware of the extremes. Clin Chem Lab Med 2004; 42: 300-304
- 23 Schulz KF, Altman DG, Moher D. ; CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ 2010; 340: c332
- 24 Dean ME, Coulter MK, Fisher P, Jobst K, Walach H. Reporting data on homeopathic treatments (RedHot): a supplement to CONSORT. Homeopathy 2007; 96: 42-45