Pharmacology for the Audiologist

Abstract

The purpose of this article is to provide a brief introduction and review regarding basic principles of pharmacology, including terminology and colloquialisms, as well as pharmacokinetic and pharmacodynamic principles of ototoxic agents. As an audiology practitioner, it is more important than ever to have a working knowledge regarding the known and proposed mechanisms of action for drugs and chemicals with known ototoxicity potential. Additionally, this article provides a discussion regarding the biochemistry behind distribution, which is a major step in determining ototoxic potential of known and potential ototoxins.

Keywords

pharmacokinetics - pharmacodynamics - ototoxicity - distribution - ADMET

• References

• 1 Hitchings AW. Monitoring drug therapy. Medicine (Baltimore) 2016; 44 (07) 427-432
• 2 Mouton JP, Njuguna C, Kramer N. , et al. Adverse drug reactions. Medicine (Baltimore) 2016; 95 (19) e3437
• 3 Maxwell SRJ. Pharmacodynamics for the prescriber. Medicine (Baltimore) 2016; 44 (07) 401-406
• 4 Hodgson J. ADMET--turning chemicals into drugs. Nat Biotechnol 2001; 19 (08) 722-726
• 5 Fan J, de Lannoy IA. Pharmacokinetics. Biochem Pharmacol 2014; 87 (01) 93-120
• 6 Buxton IO. Pharmacokinetics: the dynamics of drug absorption, distribution, metabolism, and elimination. In: Brunton LL, Hilal-Dandan R, Knollmann BC. , eds. Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13th ed. New York, NY: McGraw-Hill; 2007
• 7 Rey JA. Pharmacodynamics and pharmacokinetics. In: Winter ME. , ed. Basic Clinical Pharmacokinetics. Vancouver, WA: Applied Therapeutics, Inc; 1994: 1-18
• 8 Abdel-Rahman SM, Kauffman RE. The integration of pharmacokinetics and pharmacodynamics: understanding dose-response. Annu Rev Pharmacol Toxicol 2004; 44: 111-136
• 9 Lee DH. One-compartment open model: intravenous bolus administration. In: Shargel L, Yu AC. . eds. Applied Biopharmaceutics & Pharmacokinetics, 7th ed. New York, NY: McGraw-Hill; . Available at: http://accesspharmacy.mhmedical.com.ezproxy.pcom.edu:2048/content.aspx?bookid=1592&sectionid=100669650 . Accessed October 7, 2018
• 10 Daneman R. The blood-brain barrier in health and disease. Ann Neurol 2012; 72 (05) 648-672
• 11 Buck TP, Trahan HP, Wendel OT. Pharmacotherapeutics and patient factors. In: Campbell KCM. , ed. Pharmacology and Ototoxicity for Audiologists, 1st ed. Clifton Park, NY: Thompson Delmar Learning; 1997
• 12 Récoché I, Rousseau V, Bourrel R. , et al. Drug-drug interactions with imatinib: an observational study. Medicine (Baltimore) 2016; 95 (40) e5076
• 13 Sun H, Zhao H. Physiologic drug distribution and protein binding. In: Shargel L, Yu AC. , eds. Applied Biopharmaceutics & Pharmacokinetics, 7th ed. New York, NY: McGraw-Hill; 2012
• 14 Schmidt S, Gonzalez D, Derendorf H. Significance of protein binding in pharmacokinetics and pharmacodynamics. J Pharm Sci 2010; 99 (03) 1107-1122
• 15 Receptor theory. In: Stringer JL. , ed. Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 5th ed. New York, NY: McGraw-Hill; . Available at: http://accesspharmacy.mhmedical.com.ezproxy.pcom.edu:2048/content.aspx?bookid=2147&sectionid=161350965 . Accessed November 1, 2018
• 16 Baca QJ, Golan DE. Pharmacokinetics. In: Golan DE, Tashjian AH, Armstrong EJ, Armstrong AW. , eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2012
• 17 Swan EE, Mescher MJ, Sewell WF, Tao SL, Borenstein JT. Inner ear drug delivery for auditory applications. Adv Drug Deliv Rev 2008; 60 (15) 1583-1599
• 18 Salt AN. Pharmacokinetics of drug entry into cochlear fluids. Volta Review 2005; 105 (03) 277-298
• 19 Liu H, Hao J, Li KS. Current strategies for drug delivery to the inner ear. Acta Pharm Sin B 2013; (02) 86-96
• 20 Taniguchi C, Guengerich P. Drug metabolism. In: Golan DE, Tashjian AH, Armstrong EJ, Armstrong AW. , eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2012
• 21 Pirmohamed M. Pharmacogenetics for the prescriber. Medicine (Baltimore) 2016; 44: 412-415
• 22 Rischel WA, Kearns GL. , eds. Pharmacogenetics and pharmacogenomics. In: Handbook of Basic Pharmacokinetics…Including Clinical Applications, 7th ed. American Pharmacists Association; 2009
• 23 Furberg BD, Furberg CD. What are the strengths of randomized controlled trials?. In: Furberg BD. , ed. Evaluating Clinical Research: All That Glitters Is Not Gold, 2nd ed. New York, NY: Springer Science; 2007