Endoscopy 2019; 51(04): S210-S211
DOI: 10.1055/s-0039-1681797
ESGE Days 2019 ePosters
Friday, April 5, 2019 09:00 – 17:00: Colon and rectum ePosters
Georg Thieme Verlag KG Stuttgart · New York

THE RISK FOR COLORECTAL ADENOMA IS ASSOCIATED WITH LIVER FIBROSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

MC Kim
1   Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea, Republic of
,
BI Jang
1   Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea, Republic of
,
MK Kang
1   Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea, Republic of
,
JH Cho
1   Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea, Republic of
,
SB Kim
1   Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea, Republic of
,
KH Kim
1   Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea, Republic of
,
KO Kim
1   Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea, Republic of
,
SH Lee
1   Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea, Republic of
,
TN Kim
1   Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea, Republic of
› Author Affiliations
Further Information

Publication History

Publication Date:
18 March 2019 (online)

 

Aims:

Non-alcoholic fatty liver disease (NAFLD) is associated with risks for developing colorectal adenoma, which is related to various metabolic factors. However, studies on the risks of developing colorectal adenoma according to the severity of NAFLD are limited. This study aimed to evaluate the association between advanced fibrosis in NAFLD and the risk for colorectal adenoma.

Methods:

We retrospectively analyzed the data of 6,332 adults who underwent abdominal ultrasound and first-time colonoscopy on the same day in a health screening program at Yeungnam University Hospital from September 2009 to June 2017. NAFLD was diagnosed using abdominal ultrasound. We evaluated the presence of advanced fibrosis in NAFLD using various non-invasive score, which also analyzed the detection rate of colorectal adenoma according to the presence of advanced fibrosis in the subjects with NAFLD.

Results:

The subjects with NAFLD had a higher prevalence of colorectal adenoma, advanced adenoma, and multiple adenomas. In the multivariate analysis adjusting for demographic and metabolic factors, NAFLD was an independent risk factor for colorectal adenoma (adjusted odds ratio [OR], 1.15; 95% confidence interval [CI], 1.02 – 1.30), advanced adenoma (adjusted OR, 1.50; 95% CI, 1.12 – 2.01), and multiple adenomas (adjusted OR, 1.32; 95% CI, 1.01 – 1.73). When NAFLD was further stratified based on the stage of fibrosis using the non-invasive score models, the subjects with NAFLD and advanced fibrosis had a significantly higher risk for colorectal adenoma, advanced adenoma, and multiple adenomas than those with NAFLD without advanced fibrosis.

Conclusions:

NAFLD with advanced fibrosis is an independent risk factor for colorectal adenoma compared with NAFLD without advanced fibrosis.