GASTRIC ADENOMA OR EARLY GASTRIC CANCER IS AN IMPORTANT RISK FACTOR FOR COLORECTAL ADENOMA

Aims:

Patients diagnosed gastric cancer have a higher prevalence and increased risk of colorectal cancer. But few studies have investigated the risk of colorectal cancer or adenoma in patients with early gastric cancer or gastric adenoma. The purpose of this study is to investigate the prevalence of colorectal adenoma or cancer in patient with gastric adenoma and early gastric cancer.

Methods:

We performed a prospective study. From January 2015 to December 2016, 110 patients who had treated stomach ESD due to early gastric cancer or adenoma were enrolled. Healthy age- and sex-matched controls were enrolled from general screening population. Demographic factors and colonoscopic findings of the cases and the controls were collected and prevalence and risk factor of colorectal adenoma and cancer of both groups are analyzed.

Results:

Data from 110 patient in the gastric neoplasm group (93 with gastric adenoma, 17 early gastric cancer) and 110 healthy control group participants were included in the statisti-cal analysis. The presence of gastric adenoma or early gastric cancer was an independent risk factor for colorectal adenoma (OR = 2.52 (1.34 – 4.75. P = 0.004) and colorectal advanced adenoma (OR = 3.19, 95% CI = 1.07 – 9.53, P = 0.037).

Conclusions:

1. This is the first prospective randomized control study to confirm that gastric adenoma or early gastric cancer is as an important risk factor for colorectal adenoma by identifying colonoscopic quality indicators that may affect adenoma detection.(High quality colonoscopy). The risk of colorectal adenoma and advanced colorectal adenoma increased significantly in patients with gastric adenoma and early gastric cancer. Therefore, we suggest that colonoscopic surveillance should be strictly considered in patient with gastric adenoma and early gastric cancer.