Endovascular Management of Massive Hematemesis due to Aorto-Esophageal Fistula

A 75-year-old man presented with weight loss, left hip pain, and dysphagia of 1-month duration. He has prior history of well-controlled diabetes and hypertension. He was clinically stable at the time of presentation with blood pressure (BP) of 160/100 mm Hg and heart rate (HR) of 82 beats/min. A radiograph of the pelvis demonstrated pathologic fracture of the left iliac bone. Contrast-enhanced computed tomography (CT) of the abdomen revealed multiple necrotic lower mediastinal nodes. During the hospital stay, there was a sudden episode of hypotension (BP of 80/60 mm Hg), tachycardia, tachypnea, and desaturation on room air. The patient was moved to the intensive care unit (ICU) and resuscitated. Hemoglobin decreased from 12 to 7 g/dL. While the patient was being moved to the CT scanner, he had a sudden episode of massive hematemesis. CT angiography of the chest demonstrated diffuse irregular circumferential mural thickening of the thoracic esophagus from D3 to D8 level with extravasation of the contrast material into the esophageal lumen ([Fig. 1A, B]). A nipple was noted in the anterior wall of the thoracic aorta at the level of D5 vertebral body ([Fig. 1C]). Based on these findings, aortoesophageal fistula was diagnosed.

Fig. 1 (A) Axial contrast-enhanced CT at the level of carina demonstrating irregular circumferential mural thickening of the thoracic oesophagus (arrow) with obvious extravasation of contrast from the aorta (asterisk). (B) Sagittal reformatted CT image demonstrates the fistulous tract (arrow head) with opacification of the esophagus. The extravasated contrast is noted in the lower thoracic esophagus (arrow). (C) Sagittal CT aortogram image demonstrating a focal nipple of the anterior aortic wall at the level of D5 vertebra (arrow). There is also heterogeneous soft tissue mass in the esophagus with few air pockets within.

Endovascular management was planned for immediate treatment of the aortoesophageal fistula. Aortography from a left femoral arterial access did not reveal any obvious extravasation. Mild luminal narrowing was seen at the level of isthmus (arrows). A correlative perioperative endoscopy was performed in the angiography suite that confirmed presence of extensive intraluminal esophageal blood clots at D3 level. Right femoral arterial cutdown was performed. A 30- × 30- × 80-mm stent graft system (Ankura; Lifetech Scientific) was advanced into the arch of aorta beyond the left subclavian artery (LSCA) over a stiff guidewire positioned within the ascending aorta ([Fig. 2A]). The uncovered portion of the stent was deployed to extend beyond the LSCA ostium, and the covered portion of the stent extended across 70% of the ostium of the LSCA ([Fig. 2B]). The distal portion of the stent was deployed at the level of inferior margin of D6 vertebra. Poststent aortography showed good antegrade flow across the graft without any extravasation. There was mild delayed but persistent antegrade flow through the LSCA ([Fig. 2C]). There were no procedural or immediate postprocedural complications.

Fig. 2 (A) A 30- × 30- × 80-mm Ankura TAA stent graft system from Lifetech was placed across the proximal descending thoracic aorta, proximally from the LSCA ostium up to the level of inferior border of D6 vertebra. (B) The ostium of the LSCA was partially occluded by the covered portion of the stent graft (indicated by the arrow). (C) Postdeployment check digital subtraction aortogram showing normal filling of the aorta and left subclavian artery (asterisk) with no obvious contrast extravasation.

Endoscopic evaluation the following day revealed ulceroproliferative tumor growth, and biopsy confirmed esophageal squamous cell carcinoma. The patient had a few episodes of melena for up to 48 hours. However, there was no change in hemoglobin. Esophageal stenting was deferred in view of reduced life expectancy due to advanced malignancy. A feeding gastrostomy tube was placed. The patient was hemodynamically stable. After 3 weeks, he developed aspiration pneumonia and eventually died due to uncontrolled septicemia.

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