Digestive Disease Interventions 2019; 03(02): 155-162
DOI: 10.1055/s-0039-1679936
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Interventional Oncology in Immuno-Oncology Part 2: Transcatheter Therapies

Meaghan Dendy Case
1   Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut
,
Ryan Slovak
1   Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut
2   University of Connecticut School of Medicine, Farmington, Connecticut
,
Junaid Raja
1   Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut
,
Hyun S. Kim
1   Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut
3   Division of Medical Oncology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut
4   Yale Cancer Center, Yale School of Medicine, New Haven, New Haven, Connecticut
› Author Affiliations

Acknowledgments and Funding HSK is supported by the United States Department of Defense (CA160741).
Further Information

Publication History

17 December 2018

23 December 2018

Publication Date:
20 March 2019 (online)

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Abstract

The use of transcatheter embolization in its various forms in interventional oncology has altered the treatment paradigms for multiple types of cancer. Though direct investigation of the immunologic effects of transcatheter treatments has been limited, research on radiation therapy can be extrapolated to better understand the potential effects of radioembolization and studies on the immune response to chemotherapy can potentially explain the immune response to hepatic artery infusion and chemoembolization. Utilization of newer systemic immunotherapies in combination with various transcatheter therapies also presents the potential for improving outcomes for multiple malignancies. This review will discuss the role of transcatheter therapies in stimulating an immune response as well as the potential these techniques have to enhance the effects of systemic immunotherapy.