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Digestive Disease Interventions 2019; 03(02): 143-154
DOI: 10.1055/s-0039-1679935
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Interventional Oncology in Immuno-Oncology Part 1: Thermal Ablation

Ryan Slovak
1   Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut
2   University of Connecticut School of Medicine, Farmington, Connecticut
,
Junaid Raja
1   Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut
,
Meaghan Dendy Case
1   Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut
,
Hyun S. Kim
1   Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut
3   Division of Medical Oncology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut
4   Yale Cancer Center, Yale School of Medicine, New Haven, New Haven, Connecticut
› Institutsangaben
Acknowledgments and Funding HSK is supported by the United States Department of Defense (CA160741).
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Publikationsverlauf

17. Dezember 2018

23. Dezember 2018

Publikationsdatum:
20. März 2019 (online)

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Abstract

Thermal ablation occupies a unique position among the various modalities available to treat malignancies. Initially utilized as a minimally invasive form of palliation, ablative techniques are increasingly being recognized for their role in activating an immune response. Locally destructive, but not thoroughly extirpative, thermal ablation function to generate an in situ tumor vaccine capable of stimulating and enhancing both innate and adaptive immune responses. As monotherapy, the response engendered remains therapeutically insufficient, but newer data suggests that when used as an adjuvant or neoadjuvant, ablation may synergistically boost the anticancer immune response produced by other, sequentially acting immunotherapies. The purpose of this review is to discuss the local and systemic immunological effects induced by thermal ablation. Radio frequency, microwave, and cryoablation will all be considered in addition to focused ultrasound ablation.

Keywords

immuno-oncology - cryoablation - vaccine - radio frequency ablation