Sinonasal Solitary Fibrous Tumor: A Review of the National Cancer Database

Objectives/Hypotheses: Sinonasal solitary fibrous tumors (SFT), also called hemangiopericytomas, are uncommon vascular tumors of the nasal cavity. Given the rarity of this disease, limited large-scale studies are available. This study describes the incidence and determinants of survival of patients with sinonasal SFT between the years of 2004 and 2014 using the National Cancer Database (NCDB).

Design: Retrospective, population-based cohort study.

Setting: Tertiary academic medical center.

Participants: Patients diagnosed with sinonasal SFT or hemangiopericytoma between 2004 and 2014 within the NCDB.

Main Outcome Measures: Overall survival (OS).

Results: A total of 40 patients were identified. Mean age at diagnosis was 55.3 years and the cohort was composed of 50.0% males. The majority of patients diagnosed with sinonasal SFT were white (82.5%) followed by black (12.5%) and Asian (5%). Most patients had no significant comorbidities with Charlson/Deyo score of 0 (75.0%) and few had Charlson/Deyo score of 2 or greater (2.5%).The nasal cavity was the most common primary site, accounting for 50.0% of cases, with over 50% of tumors being 4 cm in size or greater. All patients underwent surgery, 30.0% received radiation, and 2.6% had chemotherapy. Of the patients with data regarding surgical approach, 56.3% had an endoscopic resection. Overall survival (OS) at 5 and 10 years was 100 and 67%, respectively.

Conclusion: Solitary fibrous tumor is a rare sinonasal malignancy with excellent prognosis overall. Surgical resection remains the gold standard in the management of sinonasal SFT with endoscopic resection gaining acceptance in recent years.