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CC BY 4.0 · Rev Bras Ginecol Obstet 2019; 41(03): 203-205
DOI: 10.1055/s-0039-1678589
Case Report
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Autoimmune Progesterone Dermatitis: A Case Report

Özhan Özdemir 
1   Department of Obstetrics and Gynecology, Ankara Numune Education and Research Hospital, Ankara, Turkey
,
Gözde Girgin Yahşi
1   Department of Obstetrics and Gynecology, Ankara Numune Education and Research Hospital, Ankara, Turkey
,
Cemal Reşat Atalay
1   Department of Obstetrics and Gynecology, Ankara Numune Education and Research Hospital, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

29 September 2018

08 January 2019

Publication Date:
02 April 2019 (online)

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Abstract

Introduction Autoimmune progesterone dermatitis (APD) is a rare autoimmune dermatosis characterized by recurrent cutaneous and mucosal lesions during the luteal phase of the menstrual cycle that disappear some days after the menses.

Case Report A 34-year-old primipara woman with no significant past medical history and no prior exogenous hormone use, who presented with cyclic skin eruptions starting 1 year after the delivery. The lesions occurred ∼ 6 days before the menses and disappeared in between 1 and 2 days after the menstruation ceased. The patient was diagnosed after a positive response to an intradermal test with progesterone and was successfully treated with combined oral contraceptives. The skin eruptions have not returned since the initiation of this therapy.

Conclusion Dermatologists, gynecologists, and obstetricians should be aware of this rare entity. Furthermore, if this condition is suspected, a thorough history taking on the menstrual cycle and results of the intradermal progesterone test are mandatory.

Keywords

autoimmune - dermatitis - progesterone
 

  • References

  • 1 You HR, Yun SJ, Kim SJ, Lee SC, Won YH, Lee JB. Three cases of autoimmune progesterone dermatitis. Ann Dermatol 2017; 29 (04) 479-482 . Doi: 10.5021/ad.2017.29.4.479
    CrossrefPubMedGoogle Scholar
  • 2 Géber HIV. Einige daten zur pathologie der urticaria menstruationalis. Dermatol Z 1921; 32: 143-150 . Doi: 10.1159/000248242
    CrossrefPubMedGoogle Scholar
  • 3 Nguyen T, Razzaque Ahmed A. Autoimmune progesterone dermatitis: Update and insights. Autoimmun Rev 2016; 15 (02) 191-197 . Doi: 10.1016/j.autrev.2015.11.003
    CrossrefPubMedGoogle Scholar
  • 4 García-Ortega P, Scorza E. Progesterone autoimmune dermatitis with positive autologous serum skin test result. Obstet Gynecol 2011; 117 (2 Pt 2): 495-498 . Doi: 10.1097/AOG.0b013e318206cb2c
    CrossrefPubMedGoogle Scholar
  • 5 Warin AP. Case 2. Diagnosis: erythema multiforme as a presentation of autoimmune progesterone dermatitis. Clin Exp Dermatol 2001; 26 (01) 107-108 . Doi: 10.1046/j.1365-2230.2001.00747.x
    CrossrefPubMedGoogle Scholar
  • 6 Detrixhe A, Nikkels AF, Dezfoulian B. Autoimmune progesterone dermatitis. Arch Gynecol Obstet 2017; 296 (05) 1013-1014 . Doi: 10.1007/s00404-017-4497-3
    CrossrefPubMedGoogle Scholar
  • 7 Drayer SM, Laufer LR, Farrell ME. Autoimmune progesterone dermatitis presenting as Stevens-Johnson syndrome. Obstet Gynecol 2017; 130 (04) 881-884 . Doi: 10.1097/AOG.0000000000002256
    CrossrefPubMedGoogle Scholar
  • 8 Kaygusuz I, Gumus II, Sarifakioglu E, Eser A, Bozkurt B, Kafali H. Autoimmune progesterone dermatitis. Taiwan J Obstet Gynecol 2014; 53 (03) 420-422 . Doi: 10.1016/j.tjog.2013.12.007
    CrossrefPubMedGoogle Scholar