Three-Dimensional Surface Reconstruction of the Human Cochlear Nucleus: Implications for Auditory Brain Stem Implant Design
04. Juni 2018
15. Dezember 2018
22. Februar 2019 (online)
Objective The auditory brain stem implant (ABI) is a neuroprosthesis placed on the surface of the cochlear nucleus (CN) to provide hearing sensations in children and adults who are not candidates for cochlear implantation. Contemporary ABI arrays are stiff and do not conform to the curved brain stem surface. Recent advancements in microfabrication techniques have enabled the development of flexible surface arrays, but these have only been applied in animal models. Herein, we measure the surface curvature of the human CN and adjoining regions to assist in the design and placement of next-generation conformable clinical ABI arrays. Three-dimensional (3D) reconstructions from ultrahigh T1-weighted brain magnetic resonance imaging (MRI) sequences and histologic reconstructions based on postmortem adult human brain stem specimens were used.
Design This is a retrospective review of radiologic data and postmortem histologic axial sections.
Setting This is set at the tertiary referral center.
Participants Data were acquired from healthy adults.
Main Outcome Measures The main outcome measures are principal curvature values (Kmin and Kmax) and global radius of curvature.
Results The CN was successfully extracted and rendered as a 3D surface in all cases. Significant curvatures of the CN in both histologic and radiographic reconstructions were found with global radius of curvature ranging from 2.08 to 8.5 mm. In addition, local curvature analysis revealed that the surface is highly complex.
Conclusion Detailed rendering of the human CN is feasible using histology and 3D MRI reconstruction and highlights complex surface topography that is not recapitulated by contemporary stiff ABI arrays.
* These authors contributed equally to this study.
- 1 Puram SV, Lee DJ. Pediatric auditory brainstem implant surgery. Otolaryngol Clin North Am 2015; 48 (06) 1117-1148
- 2 Kaplan AB, Kozin ED, Puram SV. , et al. Auditory brainstem implant candidacy in the United States in children 0-17 years old. Int J Pediatr Otorhinolaryngol 2015; 79 (03) 310-315
- 3 Colletti L, Shannon R, Colletti V. Auditory brainstem implants for neurofibromatosis type 2. Curr Opin Otolaryngol Head Neck Surg 2012; 20 (05) 353-357
- 4 Colletti V, Shannon RV, Carner M, Veronese S, Colletti L. Progress in restoration of hearing with the auditory brainstem implant. Prog Brain Res 2009; 175: 333-345
- 5 Colletti V, Sacchetto L, Giarbini N, Fiorino F, Carner M. Retrosigmoid approach for auditory brainstem implant. J Laryngol Otol Suppl 2000; (27) 37-40
- 6 Nakatomi H, Miyawaki S, Kin T, Saito N. Hearing restoration with auditory brainstem implant. Neurol Med Chir (Tokyo) 2016; 56 (10) 597-604
- 7 Puram SV, Barber SR, Kozin ED. , et al. Outcomes following pediatric auditory brainstem implant surgery: early experiences in a North American center. Otolaryngol Head Neck Surg 2016; 155 (01) 133-138
- 8 Noij KS, Kozin ED, Sethi R. , et al. Systematic review of nontumor pediatric auditory brainstem implant outcomes. Otolaryngol Head Neck Surg 2015; 153 (05) 739-750
- 9 McSorley A, Freeman SR, Ramsden RT. , et al. Subjective outcomes of auditory brainstem implantation. Otol Neurotol 2015; 36 (05) 873-878
- 10 Behr R, Colletti V, Matthies C. , et al. New outcomes with auditory brainstem implants in NF2 patients. Otol Neurotol 2014; 35 (10) 1844-1851
- 11 Sanna M, Di Lella F, Guida M, Merkus P. Auditory brainstem implants in NF2 patients: results and review of the literature. Otol Neurotol 2012; 33 (02) 154-164
- 12 Colletti V, Shannon RV. Open set speech perception with auditory brainstem implant?. Laryngoscope 2005; 115 (11) 1974-1978
- 13 Rosahl SK, Rosahl S. No easy target: anatomic constraints of electrodes interfacing the human cochlear nucleus. Neurosurgery 2013; 72 (1, Suppl Operative): 58-64 , discussion 65
- 14 Barber SR, Kozin ED, Remenschneider AK. , et al. Auditory brainstem implant array position varies widely among adult and pediatric patients and is associated with perception. Ear Hear 2017; 38 (06) e343-e351
- 15 Guex AA, Vachicouras N, Hight AE, Brown MC, Lee DJ, Lacour SP. Conducting polymer electrodes for auditory brainstem implants. J Mater Chem B Mater Biol Med 2015; 3 (25) 5021-5027
- 16 Minev IR, Musienko P, Hirsch A. , et al. Biomaterials. Electronic dura mater for long-term multimodal neural interfaces. Science 2015; 347 (6218): 159-163
- 17 Bloch J, Lacour SP, Courtine G. Electronic dura mater meddling in the central nervous system. JAMA Neurol 2017; 74 (04) 470-475
- 18 Hirsch A, Michaud HO, Gerratt AP, de Mulatier S, Lacour SP. Intrinsically stretchable biphasic (solid-liquid) thin metal films. Adv Mater 2016; 28 (22) 4507-4512
- 19 Py C, Reverdy P, Doppler L, Bico J, Roman B, Baroud CN. Capillarity induced folding of elastic sheets. Eur Phys J Spec Top 2009; 166 (01) 67-71
- 20 Lüsebrink F, Sciarra A, Mattern H, Yakupov R, Speck O. T1-weighted in vivo human whole brain MRI dataset with an ultrahigh isotropic resolution of 250 μm. Sci Data 2017; 4: 170032
- 21 Lusebrink F, Sciarra A, Mattern H, Yakupov R, Speck O. T1-weighted in vivo human whole brain MRI dataset with an ultrahigh isotropic resolution of 250 mum. Dryad Digital Repository Web site. Available at: https://datadryad.org/resource/doi:10.5061/dryad.38s74 . Updated 2017
- 22 Besl PJ, Jain RC. Invariant surface characteristics for 3D object recognition in range images. Comput Vis Graph Image Process 1986; 33 (01) 33-80
- 23 Parra-Denis E, Moulin N, Jeulin D. Three dimensional complex shapes analysis from 3d local curvature measurements. application to intermetallic particles in aluminium alloy 5xxx. Image Anal Stereol 2011; 26 (03) 157-164
- 24 Cohen-Steiner D, Morvan J. Restricted Delaunay triangulations and normal cycle. J Assoc Comput Mach 2003; •••: 312-321
- 25 Sumith Y. Fast geometric fit algorithm for sphere using exact solution. arXiv.org Web site. Available at: https://arxiv.org/abs/1506.02776 . Accessed February 2, 2018
- 26 Rosahl SK, Rosahl S. Anatomy of the human cochlear nucleus in relation to auditory brainstem implants. World Congress on Medical Physics and Biomedical Engineering. 2009 :40–43
- 27 Quester R, Schröder R. Topographic anatomy of the cochlear nuclear region at the floor of the fourth ventricle in humans. J Neurosurg 1999; 91 (03) 466-476
- 28 Jeong JW, Shin G, Park SI, Yu KJ, Xu L, Rogers JA. Soft materials in neuroengineering for hard problems in neuroscience. Neuron 2015; 86 (01) 175-186