Hamostaseologie 2019; 39(01): 028-035
DOI: 10.1055/s-0039-1677714
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Child Abuse or Bleeding Disorder—An Interdisciplinary Approach

Ralf Knöfler
1   Department of Pediatric Hemostaseology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Children's Hospital, Dresden, Sachsen, Germany
,
Werner Streif
2   Department of Pediatrics, Medical University of Innsbruck, Innsbruck, Tirol, Austria
,
Irmina Watzer-Herberth
1   Department of Pediatric Hemostaseology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Children's Hospital, Dresden, Sachsen, Germany
,
Gabriele Hahn
3   Department of Pediatric Radiology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Sachsen, Germany
,
Uwe Schmidt
4   Institute of Forensic Medicine, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Sachsen, Germany
› Author Affiliations
Further Information

Publication History

09 October 2018

21 November 2018

Publication Date:
25 January 2019 (online)

Abstract

Children with an unexplained bleeding tendency are frequently referred to a haemostaseologist for further evaluation. Careful standardized history taking and clinical evaluation should allow for distinguishing bleeds after minor injury and trauma which are very common in all children. However, in two groups of children bleeding symptoms may be more significant than expected: those with an underlying coagulation disorder and those who have been subjected to physical child abuse. The coexistence of child abuse and a bleeding disorder must always be considered. An extended coagulation diagnostic is required if the morphology of bleedings is not clearly suspicious for child abuse and in the absence of typical concomitant injuries, e.g., bone fractures. An interdisciplinary approach involving a forensic pathologist and a paediatric haemostaseologist for assessment of bleeding symptoms, the explanation of the clinical findings, and the critical evaluation of laboratory results are essential in such cases. This review is focussed on symptoms in accidental and nonaccidental injuries in children assisting haemostaseologists in decision making in cases of child protection issues.

Zusammenfassung

Kinder mit unklarer Blutungsneigung werden häufig zum Hämostaseologen zur Abklärung geschickt. Eine standardisierte Ananmneseerhebung und klinische Untersuchung erlauben es zu entscheiden, ob es sich um Blutungen durch kleine Verletzungen und Traumata handelt. In der Regel treten bei 2 Gruppen von Kindern relevante Blutungen auf: Kinder mit Gerinnungsstörung und solche, die körperlich misshandelt werden. Dabei ist stets zu berücksichtigen, dass auch gleichzeitig eine Gerinnungsstörung und eine Misshandlung vorliegen kann. Eine erweiterte Gerinnungsdiagnostik ist erforderlich, wenn die Blutungsmorphe nicht eindeutig für eine Misshandlung spricht und beim Fehlen typischer Begleitverletzungen, wie Frakturen. In diesen Fällen ist ein interdisziplinäres Vorgehen unter Einbeziehung eines Rechtsmediziners und eines pädiatrischen Hämostaseologen zur Beurteilung der Symptome, den Erklärungen für das vorliegende klinische Bild und eine kritische Bewertung der Befunde der Gerinnungsdiagnostik notwendig. Diese Übersichtsarbeit fokussiert auf Symptome bei akzidentellen und nicht-akzidentellen Verletzungen und soll eine Entscheidungshilfe für Hämostaseologen in Kinderschutzfällen darstellen.

 
  • References

  • 1 Khair K, Liesner R. Bruising and bleeding in infants and children--a practical approach. Br J Haematol 2006; 133 (03) 221-231
  • 2 Sibert J. Bruising, coagulation disorder, and physical child abuse. Blood Coagul Fibrinolysis 2004; 15 (Suppl. 01) S33-S39
  • 3 Herrmann B. Körperliche Misshandlung von Kindern. Somatische Befunde und klinische Diagnostik. Monatsschr Kinderheilkd 2002; 150: 1324-1338
  • 4 Sorantin E, Lindbichler F. Die nicht unfallbedingte Verletzung (battered child). Monatsschr Kinderheilkd 2002; 150: 1068-1075
  • 5 Herrmann B. Hautbefunde bei Kindesmisshandlung – Machen blaue Flecken krank?. Monatsschr Kinderheilkd 2005; 153: 1077-1081
  • 6 Nayak K, Spencer N, Shenoy M, Rubithon J, Coad N, Logan S. How useful is the presence of petechiae in distinguishing non-accidental from accidental injury?. Child Abuse Negl 2006; 30 (05) 549-555
  • 7 Jaffe FA. Petechial hemorrhages. A review of pathogenesis. Am J Forensic Med Pathol 1994; 15 (03) 203-207
  • 8 Herrmann B, Dettmeyer R, Banaschak S, Thyen U. Kindesmisshandlung. Berlin: Springer; 2010: 51-71
  • 9 Duhaime AC, Christian CW, Rorke LB, Zimmerman RA. Nonaccidental head injury in infants--the “shaken-baby syndrome”. N Engl J Med 1998; 338 (25) 1822-1829
  • 10 Karibe H, Kameyama M, Hayashi T, Narisawa A, Tominaga T. Acute subdural hematoma in infants with abusive head trauma: a literature review. Neurol Med Chir (Tokyo) 2016; 56 (05) 264-273
  • 11 Reece RM, Sege R. Childhood head injuries: accidental or inflicted?. Arch Pediatr Adolesc Med 2000; 154 (01) 11-15
  • 12 Adamo MA, Drazin D, Smith C, Waldman JB. Comparison of accidental and nonaccidental traumatic brain injuries in infants and toddlers: demographics, neurosurgical interventions, and outcomes. J Neurosurg Pediatr 2009; 4 (05) 414-419
  • 13 Alexander RC, Levitt CJ, Smith WL. Abusive head trauma. In: Reece RM, Ludwig S. , eds. Child Abuse – Medical Diagnosis and Management. Philadelphia, PA: Lippincott Williams & Wilkins; 2001: 47-80
  • 14 Herrmann B, Dettmeyer R, Banaschak S, Thyen U. Kindesmisshandlung – Medizinische Diagnostik, Intervention und rechtliche Grundlagen. Berlin: Springer; 2016
  • 15 Herrmann B. Nicht akzidentelle Kopfverletzungen und Schütteltrauma. Klinische und pathophysiologische Aspekte. Rechtsmedizin 2008; 18: 9-16
  • 16 Gilliland MGF, Luckenbach MW, Chenier TC. Systemic and ocular findings in 169 prospectively studied child deaths: retinal hemorrhages usually mean child abuse. Forensic Sci Int 1994; 68 (02) 117-132
  • 17 Bechtel K, Stoessel K, Leventhal JM. , et al. Characteristics that distinguish accidental from abusive injury in hospitalized young children with head trauma. Pediatrics 2004; 114 (01) 165-168
  • 18 Hartley LM, Khwaja OS, Verity CM. Glutaric aciduria type 1 and nonaccidental head injury. Pediatrics 2001; 107 (01) 174-175
  • 19 Gago LC, Wegner RK, Capone Jr A, Williams GA. Intraretinal hemorrhages and chronic subdural effusions: glutaric aciduria type 1 can be mistaken for shaken baby syndrome. Retina 2003; 23 (05) 724-726
  • 20 Scholl-Bürgi S, Kapelari K, Michel M, Pavlic M, Streif W, Karall D. Angeborene Stoffwechselstörungen in der Differenzialdiagnose von Kindesmisshandlung. Pädiatrische Praxis 2016; 86: 273-283
  • 21 Nassogne MC, Sharrard M, Hertz-Pannier L. , et al. Massive subdural haematomas in Menkes disease mimicking shaken baby syndrome. Childs Nerv Syst 2002; 18 (12) 729-731
  • 22 Levy HL, Brown AE, Williams SE, de Juan Jr E. Vitreous hemorrhage as an ophthalmic complication of galactosemia. J Pediatr 1996; 129 (06) 922-925
  • 23 Emerson MV, Pieramici DJ, Stoessel KM, Berreen JP, Gariano RF. Incidence and rate of disappearance of retinal hemorrhage in newborns. Ophthalmology 2001; 108 (01) 36-39
  • 24 Whitby EH, Griffiths PD, Rutter S. , et al. Frequency and natural history of subdural haemorrhages in babies and relation to obstetric factors. Lancet 2004; 363 (9412): 846-851
  • 25 Tabibian S, Motlagh H, Naderi M, Dorgalaleh A. Intracranial hemorrhage in congenital bleeding disorders. Blood Coagul Fibrinolysis 2018; 29 (01) 1-11
  • 26 Psaila B, Petrovic A, Page LK, Menell J, Schonholz M, Bussel JB. Intracranial hemorrhage (ICH) in children with immune thrombocytopenia (ITP): study of 40 cases. Blood 2009; 114 (23) 4777-4783
  • 27 Li-McLeod J, Xiong Y, Ito L, Epstein J. The incidence and impact of intracranial hemorrhages within a hemophilia and non-hemophilia population. J Thromb Haemost 2013; 11: 528
  • 28 Andersson NG, Auerswald G, Barnes C. , et al. Intracranial haemorrhage in children and adolescents with severe haemophilia A or B - the impact of prophylactic treatment. Br J Haematol 2017; 179 (02) 298-307
  • 29 Karimi M, Bereczky Z, Cohan N, Muszbek L. Factor XIII deficiency. Semin Thromb Hemost 2009; 35 (04) 426-438
  • 30 Music I, Novak M, Acham-Roschitz B, Muntean W. Screening for haemorrhagic disorders in paediatric patients by means of a questionnaire. Hamostaseologie 2009; 29 (Suppl. 01) S87-S89
  • 31 Bidlingmaier C, Grote V, Budde U, Olivieri M, Kurnik K. Prospective evaluation of a pediatric bleeding questionnaire and the ISTH bleeding assessment tool in children and parents in routine clinical practice. J Thromb Haemost 2012; 10 (07) 1335-1341
  • 32 Bidlingmaier C, Olivieri M, Kurnik K. Hautblutungen bei Kindern - Ist es eine Gerinnungsstörung?. Monatsschr Kinderheilkd 2012; 160: 538-544
  • 33 Newman RS, Jalili M, Kolls BJ, Dietrich R. Factor XIII deficiency mistaken for battered child syndrome: case of “correct” test ordering negated by a commonly accepted qualitative test with limited negative predictive value. Am J Hematol 2002; 71 (04) 328-330
  • 34 Olivieri M, Kurnik K, Bidlingmaier C. Coagulation testing in the evaluation of suspected child abuse. Hamostaseologie 2009; 29: 190-192
  • 35 Knöfler R, Streif W. Strategies in clinical and laboratory diagnosis of inherited platelet function disorders in children. Transfus Med Hemother 2010; 37 (05) 231-235
  • 36 Streif W, Knöfler R, Eberl W. Inherited disorders of platelet function in pediatric clinical practice: a diagnostic challenge. Klin Padiatr 2010; 222 (03) 203-208
  • 37 Knöfler R, Lohse J, Stächele J. , et al. Significance of platelet function diagnostics for clarification of suspected battered child syndrome. Hamostaseologie 2014; 34 (Suppl. 01) S53-S56
  • 38 Kurnik K, Bidlingmaier C, Hütker S, Olivieri M. Haemostatic disorders in children [in German]. Hamostaseologie 2016; 36 (02) 109-125
  • 39 Knöfler R, Schmidt U. Gerinnungsstörung, Unfall oder Misshandlung?. Stuttgart: Georg Thieme Verlag; 2018