Semin Neurol 2019; 39(01): 027-040
DOI: 10.1055/s-0038-1676857
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Acute Dizziness

Kiersten L. Gurley
1   Deparment of Emergency Medicine, Harvard Medical School, Boston, Massachusetts
2   Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
3   Department of Emergency Medicine, Mount Auburn Hospital, Cambridge, Massachusetts
,
Jonathan A. Edlow
1   Deparment of Emergency Medicine, Harvard Medical School, Boston, Massachusetts
2   Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
› Author Affiliations
Funding None.
Further Information

Publication History

Publication Date:
11 February 2019 (online)

Abstract

Dizziness is a common chief complaint with an extensive differential diagnosis that includes both benign and serious conditions. Physicians must distinguish the majority of patients who suffer from self-limiting conditions from those with serious illnesses that require acute treatment. The preferred approach to the diagnosis of an acutely dizzy patient emphasizes different aspects of the history to guide a focused physical examination, with the goal of differentiating benign peripheral vestibular conditions from dangerous posterior circulation strokes. Currently, misdiagnoses are frequent and diagnostic testing costs are high. This partly relates to use of an outdated diagnostic paradigm. This commonly used traditional approach relies on dizziness “symptom quality” or “type” (vertigo, presyncope, disequilibrium) to guide inquiry. It does not distinguish benign from dangerous causes and is inconsistent with current best evidence. A better approach categorizes patients into three groups based on timing and triggers. Each category has its own differential diagnosis and targeted bedside approach: (1) acute vestibular syndrome, where bedside physical examination differentiates vestibular neuritis from stroke; (2) spontaneous episodic vestibular syndrome, where associated symptoms help differentiate vestibular migraine from transient ischemic attack; and (3) triggered episodic vestibular syndrome, where the Dix-Hallpike and supine roll test help differentiate benign paroxysmal positional vertigo from posterior fossa structural lesions. The “timing and triggers” diagnostic approach for the acutely dizzy derives from current best evidence and offers the potential to reduce misdiagnosis while simultaneously decreasing diagnostic test overuse, unnecessary hospitalization, and incorrect treatments.

 
  • References

  • 1 Newman-Toker DE, Hsieh YH, Camargo Jr CA, Pelletier AJ, Butchy GT, Edlow JA. Spectrum of dizziness visits to US emergency departments: cross-sectional analysis from a nationally representative sample. Mayo Clin Proc 2008; 83 (07) 765-775
  • 2 Cheung CS, Mak PS, Manley KV. , et al. Predictors of important neurological causes of dizziness among patients presenting to the emergency department. Emerg Med J 2010; 27 (07) 517-521
  • 3 Saber Tehrani AS, Kattah JC, Kerber KA. , et al. Diagnosing stroke in acute dizziness and vertigo: pitfalls and pearls. Stroke 2018; 49 (03) 788-795
  • 4 Edlow JA, Gurley KL, Newman-Toker DE. A new diagnostic approach to the adult patient with acute dizziness. J Emerg Med 2018; 54 (04) 469-483
  • 5 Saber Tehrani AS, Coughlan D, Hsieh YH. , et al. Rising annual costs of dizziness presentations to U.S. emergency departments. Acad Emerg Med 2013; 20 (07) 689-696
  • 6 Newman-Toker DE. Missed stroke in acute vertigo and dizziness: it is time for action, not debate. Ann Neurol 2016; 79 (01) 27-31
  • 7 Newman-Toker DE, McDonald KM, Meltzer DO. How much diagnostic safety can we afford, and how should we decide? A health economics perspective. BMJ Qual Saf 2013; 22 (Suppl. 02) ii11-ii20
  • 8 Improving Diagnosis in Health Care. Washington, DC: National Academies Press; 2015
  • 9 Tarnutzer AA, Lee SH, Robinson KA, Wang Z, Edlow JA, Newman-Toker DE. ED misdiagnosis of cerebrovascular events in the era of modern neuroimaging: a meta-analysis. Neurology 2017; 88 (15) 1468-1477
  • 10 Edlow JA, Newman-Toker D. Using the physical examination to diagnose patients with acute dizziness and vertigo. J Emerg Med 2016; 50 (04) 617-628
  • 11 Kerber KA, Newman-Toker DE. Misdiagnosing dizzy patients: common pitfalls in clinical practice. Neurol Clin 2015; 33 (03) 565-575 , viii
  • 12 Newman-Toker DE, Edlow JA. TiTrATE: a novel, evidence-based approach to diagnosing acute dizziness and vertigo. Neurol Clin 2015; 33 (03) 577-599 , viii
  • 13 Newman-Toker DE. Symptoms and signs of neuro-otologic disorders. Continuum (Minneap Minn) 2012; 18 (5 Neuro-otology): 1016-1040
  • 14 Edlow JA, Newman-Toker DE, Savitz SI. Diagnosis and initial management of cerebellar infarction. Lancet Neurol 2008; 7 (10) 951-964
  • 15 Navi BB, Kamel H, Shah MP. , et al. Rate and predictors of serious neurologic causes of dizziness in the emergency department. Mayo Clin Proc 2012; 87 (11) 1080-1088
  • 16 Chase M, Joyce NR, Carney E. , et al. ED patients with vertigo: can we identify clinical factors associated with acute stroke?. Am J Emerg Med 2012; 30 (04) 587-591
  • 17 Moubayed SP, Saliba I. Vertebrobasilar insufficiency presenting as isolated positional vertigo or dizziness: a double-blind retrospective cohort study. Laryngoscope 2009; 119 (10) 2071-2076
  • 18 Kerber KA, Meurer WJ, Brown DL. , et al. Stroke risk stratification in acute dizziness presentations: a prospective imaging-based study. Neurology 2015; 85 (21) 1869-1878
  • 19 Navi BB, Kamel H, Shah MP. , et al. Application of the ABCD2 score to identify cerebrovascular causes of dizziness in the emergency department. Stroke 2012; 43 (06) 1484-1489
  • 20 Drachman DA, Hart CW. An approach to the dizzy patient. Neurology 1972; 22 (04) 323-334
  • 21 Newman-Toker D. Diagnosing Dizziness in the Emergency Department: Why “What Do You Mean by 'Dizzy'?” Should Not Be the First Question You Ask [PhD]. Baltimore, MD: Johns Hopkins School of Medicine; 2007
  • 22 Edlow JA. Diagnosing dizziness: we are teaching the wrong paradigm!. Acad Emerg Med 2013; 20 (10) 1064-1066
  • 23 Newman-Toker DE. Charted records of dizzy patients suggest emergency physicians emphasize symptom quality in diagnostic assessment. Ann Emerg Med 2007; 50 (02) 204-205
  • 24 Newman-Toker DE, Cannon LM, Stofferahn ME, Rothman RE, Hsieh YH, Zee DS. Imprecision in patient reports of dizziness symptom quality: a cross-sectional study conducted in an acute care setting. Mayo Clin Proc 2007; 82 (11) 1329-1340
  • 25 Kerber KA, Brown DL, Lisabeth LD, Smith MA, Morgenstern LB. Stroke among patients with dizziness, vertigo, and imbalance in the emergency department: a population-based study. Stroke 2006; 37 (10) 2484-2487
  • 26 Newman-Toker DE, Dy FJ, Stanton VA, Zee DS, Calkins H, Robinson KA. How often is dizziness from primary cardiovascular disease true vertigo? A systematic review. J Gen Intern Med 2008; 23 (12) 2087-2094
  • 27 Lawson J, Johnson I, Bamiou DE, Newton JL. Benign paroxysmal positional vertigo: clinical characteristics of dizzy patients referred to a Falls and Syncope Unit. QJM 2005; 98 (05) 357-364
  • 28 Stanton VA, Hsieh YH, Camargo Jr CA. , et al. Overreliance on symptom quality in diagnosing dizziness: results of a multicenter survey of emergency physicians. Mayo Clin Proc 2007; 82 (11) 1319-1328
  • 29 Royl G, Ploner CJ, Leithner C. Dizziness in the emergency room: diagnoses and misdiagnoses. Eur Neurol 2011; 66 (05) 256-263
  • 30 Braun EM, Tomazic PV, Ropposch T, Nemetz U, Lackner A, Walch C. Misdiagnosis of acute peripheral vestibulopathy in central nervous ischemic infarction. Otol Neurotol 2011; 32 (09) 1518-1521
  • 31 Casani AP, Dallan I, Cerchiai N, Lenzi R, Cosottini M, Sellari-Franceschini S. Cerebellar infarctions mimicking acute peripheral vertigo: how to avoid misdiagnosis?. Otolaryngol Head Neck Surg 2013; 148 (03) 475-481
  • 32 Lee H, Sohn SI, Cho YW. , et al. Cerebellar infarction presenting isolated vertigo: frequency and vascular topographical patterns. Neurology 2006; 67 (07) 1178-1183
  • 33 Lavallée PC, Meseguer E, Abboud H. , et al. A transient ischaemic attack clinic with round-the-clock access (SOS-TIA): feasibility and effects. Lancet Neurol 2007; 6 (11) 953-960
  • 34 Rothwell PM, Giles MF, Chandratheva A. , et al; Early Use of Existing Preventive Strategies for Stroke (EXPRESS) Study. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet 2007; 370 (9596): 1432-1442
  • 35 Savitz SI, Caplan LR, Edlow JA. Pitfalls in the diagnosis of cerebellar infarction. Acad Emerg Med 2007; 14 (01) 63-68
  • 36 Kuruvilla A, Bhattacharya P, Rajamani K, Chaturvedi S. Factors associated with misdiagnosis of acute stroke in young adults. J Stroke Cerebrovasc Dis 2011; 20 (06) 523-527
  • 37 Martin-Schild S, Albright KC, Tanksley J. , et al. Zero on the NIHSS does not equal the absence of stroke. Ann Emerg Med 2011; 57 (01) 42-45
  • 38 Mandelzweig L, Goldbourt U, Boyko V, Tanne D. Perceptual, social, and behavioral factors associated with delays in seeking medical care in patients with symptoms of acute stroke. Stroke 2006; 37 (05) 1248-1253
  • 39 Masuda Y, Tei H, Shimizu S, Uchiyama S. Factors associated with the misdiagnosis of cerebellar infarction. J Stroke Cerebrovasc Dis 2013; 22 (07) 1125-1130
  • 40 Newman-Toker DE, Moy E, Valente E, Coffey R, Hines AL. Missed diagnosis of stroke in the ED: a cross-sectional analysis of a large population based sample. Diagnosis (Berl) 2014; 2: 29-40
  • 41 Honda S, Inatomi Y, Yonehara T. , et al. Discrimination of acute ischemic stroke from nonischemic vertigo in patients presenting with only imbalance. J Stroke Cerebrovasc Dis 2014; 23 (05) 888-895
  • 42 Nakajima M, Hirano T, Uchino M. Patients with acute stroke admitted on the second visit. J Stroke Cerebrovasc Dis 2008; 17 (06) 382-387
  • 43 Lee CC, Ho HC, Su YC. , et al. Increased risk of vascular events in emergency room patients discharged home with diagnosis of dizziness or vertigo: a 3-year follow-up study. PLoS One 2012; 7 (04) e35923
  • 44 Kerber KA, Morgenstern LB, Meurer WJ. , et al. Nystagmus assessments documented by emergency physicians in acute dizziness presentations: a target for decision support?. Acad Emerg Med 2011; 18 (06) 619-626
  • 45 Newman-Toker DE, Camargo Jr CA, Hsieh YH, Pelletier AJ, Edlow JA. Disconnect between charted vestibular diagnoses and emergency department management decisions: a cross-sectional analysis from a nationally representative sample. Acad Emerg Med 2009; 16 (10) 970-977
  • 46 Tarnutzer AA, Berkowitz AL, Robinson KA, Hsieh YH, Newman-Toker DE. Does my dizzy patient have a stroke? A systematic review of bedside diagnosis in acute vestibular syndrome. CMAJ 2011; 183 (09) E571-E592
  • 47 Edlow JA, Newman-Toker DE. Medical and nonstroke neurologic causes of acute, continuous vestibular symptoms. Neurol Clin 2015; 33 (03) 699-716 , xi
  • 48 Pula JH, Newman-Toker DE, Kattah JC. Multiple sclerosis as a cause of the acute vestibular syndrome. J Neurol 2013; 260 (06) 1649-1654
  • 49 Kerber KA, Burke JF, Brown DL. , et al. Does intracerebral haemorrhage mimic benign dizziness presentations? A population based study. Emerg Med J 2012; 29 (01) 43-46
  • 50 Kattah JC, Dhanani SS, Pula JH, Mantokoudis G, Tehrani ASS, Toker DEN. Vestibular signs of thiamine deficiency during the early phase of suspected Wernicke encephalopathy. Neurol Clin Pract 2013; 3 (06) 460-468
  • 51 Cutfield NJ, Seemungal BM, Millington H, Bronstein AM. Diagnosis of acute vertigo in the emergency department. Emerg Med J 2011; 28 (06) 538-539
  • 52 Arbusow V, Theil D, Strupp M, Mascolo A, Brandt T. HSV-1 not only in human vestibular ganglia but also in the vestibular labyrinth. Audiol Neurotol 2001; 6 (05) 259-262
  • 53 Lu YC, Young YH. Vertigo from herpes zoster oticus: superior or inferior vestibular nerve origin?. Laryngoscope 2003; 113 (02) 307-311
  • 54 Strupp M, Jäger L, Müller-Lisse U, Arbusow V, Reiser M, Brandt T. High resolution Gd-DTPA MR imaging of the inner ear in 60 patients with idiopathic vestibular neuritis: no evidence for contrast enhancement of the labyrinth or vestibular nerve. J Vestib Res 1998; 8 (06) 427-433
  • 55 Baloh RW. Clinical practice. Vestibular neuritis. N Engl J Med 2003; 348 (11) 1027-1032
  • 56 Chalela JA, Kidwell CS, Nentwich LM. , et al. Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison. Lancet 2007; 369 (9558): 293-298
  • 57 Choi JH, Kim HW, Choi KD. , et al. Isolated vestibular syndrome in posterior circulation stroke: Frequency and involved structures. Neurol Clin Pract 2014; 4 (05) 410-418
  • 58 Kattah JC, Talkad AV, Wang DZ, Hsieh YH, Newman-Toker DE. HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging. Stroke 2009; 40 (11) 3504-3510
  • 59 Saber Tehrani AS, Kattah JC, Mantokoudis G. , et al. Small strokes causing severe vertigo: frequency of false-negative MRIs and nonlacunar mechanisms. Neurology 2014; 83 (02) 169-173
  • 60 Newman-Toker DE, Kerber KA, Hsieh YH. , et al. HINTS outperforms ABCD2 to screen for stroke in acute continuous vertigo and dizziness. Acad Emerg Med 2013; 20 (10) 986-996
  • 61 Chen L, Lee W, Chambers BR, Dewey HM. Diagnostic accuracy of acute vestibular syndrome at the bedside in a stroke unit. J Neurol 2011; 258 (05) 855-861
  • 62 Newman-Toker DE, Kattah JC. In reply. Acad Emerg Med 2014; 21 (03) 348-349
  • 63 Taylor RL, McGarvie LA, Reid N, Young AS, Halmagyi GM, Welgampola MS. Vestibular neuritis affects both superior and inferior vestibular nerves. Neurology 2016; 87 (16) 1704-1712
  • 64 Newman-Toker DE, Sharma P, Chowdhury M, Clemons TM, Zee DS, Della Santina CC. Penlight-cover test: a new bedside method to unmask nystagmus. J Neurol Neurosurg Psychiatry 2009; 80 (08) 900-903
  • 65 Newman-Toker DE, Curthoys IS, Halmagyi GM. Diagnosing stroke in acute vertigo: the HINTS family of eye movement tests and the future of the “eye ECG”. Semin Neurol 2015; 35 (05) 506-521
  • 66 Halmagyi GM, Curthoys IS. A clinical sign of canal paresis. Arch Neurol 1988; 45 (07) 737-739
  • 67 Newman-Toker DE, Kattah JC, Alvernia JE, Wang DZ. Normal head impulse test differentiates acute cerebellar strokes from vestibular neuritis. Neurology 2008; 70 (24, Pt 2): 2378-2385
  • 68 Häusler R, Levine RA. Auditory dysfunction in stroke. Acta Otolaryngol 2000; 120 (06) 689-703
  • 69 Lee H. Neuro-otological aspects of cerebellar stroke syndrome. J Clin Neurol 2009; 5 (02) 65-73
  • 70 Lee H, Kim JS, Chung EJ. , et al. Infarction in the territory of anterior inferior cerebellar artery: spectrum of audiovestibular loss. Stroke 2009; 40 (12) 3745-3751
  • 71 Lee SH, Kim JS. Acute diagnosis and management of stroke presenting dizziness or vertigo. Neurol Clin 2015; 33 (03) 687-698 , xi
  • 72 Newman-Toker DE, Reich SG. Wrong-way nystagmus in the AICA syndrome. [letter to the editor] Laryngoscope 2008; 118 (02) 378-379
  • 73 Pogson JM, Taylor RL, Young AS. , et al. Vertigo with sudden hearing loss: audio-vestibular characteristics. J Neurol 2016; 263 (10) 2086-2096
  • 74 Kim JS. Pure lateral medullary infarction: clinical-radiological correlation of 130 acute, consecutive patients. Brain 2003; 126 (Pt 8): 1864-1872
  • 75 Carmona S, Martínez C, Zalazar G. , et al. The diagnostic accuracy of truncal ataxia and HINTS as cardinal signs for acute vestibular syndrome. Front Neurol 2016; 7: 125
  • 76 Choi JH, Park MG, Choi SY. , et al. Acute transient vestibular syndrome: prevalence of stroke and efficacy of bedside evaluation. Stroke 2017; 48 (03) 556-562
  • 77 Neuhauser HK, Radtke A, von Brevern M. , et al. Migrainous vertigo: prevalence and impact on quality of life. Neurology 2006; 67 (06) 1028-1033
  • 78 Seemungal B, Kaski D, Lopez-Escamez JA. Early diagnosis and management of acute vertigo from vestibular migraine and Ménière's disease. Neurol Clin 2015; 33 (03) 619-628 , ix
  • 79 Strupp M, Versino M, Brandt T. Vestibular migraine. Handb Clin Neurol 2010; 97: 755-771
  • 80 Blum CA, Kasner SE. Transient ischemic attacks presenting with dizziness or vertigo. Neurol Clin 2015; 33 (03) 629-642 , ix
  • 81 Paul NL, Simoni M, Rothwell PM. ; Oxford Vascular Study. Transient isolated brainstem symptoms preceding posterior circulation stroke: a population-based study. Lancet Neurol 2013; 12 (01) 65-71
  • 82 Romme JJ, van Dijk N, Boer KR. , et al. Influence of age and gender on the occurrence and presentation of reflex syncope. Clin Auton Res 2008; 18 (03) 127-133
  • 83 Kanner AM. Ictal panic and interictal panic attacks: diagnostic and therapeutic principles. Neurol Clin 2011; 29 (01) 163-175 , ix
  • 84 Chen J, Tsuchiya M, Kawakami N, Furukawa TA. Non-fearful vs. fearful panic attacks: a general population study from the National Comorbidity Survey. J Affect Disord 2009; 112 (1-3): 273-278
  • 85 Dieterich M, Brandt T. Episodic vertigo related to migraine (90 cases): vestibular migraine?. J Neurol 1999; 246 (10) 883-892
  • 86 Mathias CJ, Deguchi K, Schatz I. Observations on recurrent syncope and presyncope in 641 patients. Lancet 2001; 357 (9253): 348-353
  • 87 Lempert T, Neuhauser H, Daroff RB. Vertigo as a symptom of migraine. Ann N Y Acad Sci 2009; 1164: 242-251
  • 88 Kayan A, Hood JD. Neuro-otological manifestations of migraine. Brain 1984; 107 (Pt 4): 1123-1142
  • 89 Sajjadi H, Paparella MM. Meniere's disease. Lancet 2008; 372 (9636): 406-414
  • 90 Furman JM, Marcus DA, Balaban CD. Vestibular migraine: clinical aspects and pathophysiology. Lancet Neurol 2013; 12 (07) 706-715
  • 91 Mancini F, Catalani M, Carru M, Monti B. History of Meniere's disease and its clinical presentation. Otolaryngol Clin North Am 2002; 35 (03) 565-580
  • 92 Faag C, Bergenius J, Forsberg C, Langius-Eklöf A. Symptoms experienced by patients with peripheral vestibular disorders: evaluation of the Vertigo Symptom Scale for clinical application. Clin Otolaryngol 2007; 32 (06) 440-446
  • 93 van Dijk JG, Thijs RD, Benditt DG, Wieling W. A guide to disorders causing transient loss of consciousness: focus on syncope. Nat Rev Neurol 2009; 5 (08) 438-448
  • 94 Moya A, Sutton R, Ammirati F. , et al; Task Force for the Diagnosis and Management of Syncope; European Society of Cardiology (ESC); European Heart Rhythm Association (EHRA); Heart Failure Association (HFA); Heart Rhythm Society (HRS). Guidelines for the diagnosis and management of syncope (version 2009). Eur Heart J 2009; 30 (21) 2631-2671
  • 95 Katon WJ. Clinical practice. Panic disorder. N Engl J Med 2006; 354 (22) 2360-2367
  • 96 Hoshino T, Nagao T, Mizuno S, Shimizu S, Uchiyama S. Transient neurological attack before vertebrobasilar stroke. J Neurol Sci 2013; 325 (1-2): 39-42
  • 97 Grad A, Baloh RW. Vertigo of vascular origin. Clinical and electronystagmographic features in 84 cases. Arch Neurol 1989; 46 (03) 281-284
  • 98 von Campe G, Regli F, Bogousslavsky J. Heralding manifestations of basilar artery occlusion with lethal or severe stroke. J Neurol Neurosurg Psychiatry 2003; 74 (12) 1621-1626
  • 99 Fisher CM. Vertigo in cerebrovascular disease. Arch Otolaryngol 1967; 85 (05) 529-534
  • 100 Gottesman RF, Sharma P, Robinson KA. , et al. Clinical characteristics of symptomatic vertebral artery dissection: a systematic review. Neurologist 2012; 18 (05) 245-254
  • 101 Shah KH, Kleckner K, Edlow JA. Short-term prognosis of stroke among patients diagnosed in the emergency department with a transient ischemic attack. Ann Emerg Med 2008; 51 (03) 316-323
  • 102 Flossmann E, Rothwell PM. Prognosis of vertebrobasilar transient ischaemic attack and minor stroke. Brain 2003; 126 (Pt 9): 1940-1954
  • 103 Gulli G, Khan S, Markus HS. Vertebrobasilar stenosis predicts high early recurrent stroke risk in posterior circulation stroke and TIA. Stroke 2009; 40 (08) 2732-2737
  • 104 Newman-Toker DE, Camargo Jr CA. ‘Cardiogenic vertigo’--true vertigo as the presenting manifestation of primary cardiac disease. Nat Clin Pract Neurol 2006; 2 (03) 167-172 , quiz 173
  • 105 Baloh RW, Honrubia V, Jacobson K. Benign positional vertigo: clinical and oculographic features in 240 cases. Neurology 1987; 37 (03) 371-378
  • 106 Fife TD, von Brevern M. Benign paroxysmal positional vertigo in the acute care setting. Neurol Clin 2015; 33 (03) 601-617 , viii–ix
  • 107 Bhattacharyya N, Baugh RF, Orvidas L. , et al; American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg 2008; 139 (05) (Suppl. 04) S47-S81
  • 108 Fife TD, Iverson DJ, Lempert T. , et al; Quality Standards Subcommittee, American Academy of Neurology. Practice parameter: therapies for benign paroxysmal positional vertigo (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2008; 70 (22) 2067-2074
  • 109 Edlow JA. Managing patients with acute episodic dizziness. Ann Emerg Med 2018; 72 (05) 602-610
  • 110 Welgampola MS, Bradshaw AP, Lechner C, Halmagyi GM. Bedside assessment of acute dizziness and vertigo. Neurol Clin 2015; 33 (03) 551-564 , vii
  • 111 Kene MV, Ballard DW, Vinson DR, Rauchwerger AS, Iskin HR, Kim AS. Emergency physician attitudes, preferences, and risk tolerance for stroke as a potential cause of dizziness symptoms. West J Emerg Med 2015; 16 (05) 768-776
  • 112 Bashir K, Qotb MA, Alkahky S, Fathi AM, Mohamed MA, Cameron PA. Are emergency physicians and paramedics providing canalith repositioning manoeuvre for benign paroxysmal positional vertigo?. Emerg Med Australas 2015; 27 (02) 179-180
  • 113 Kerber KA, Burke JF, Skolarus LE. , et al. Use of BPPV processes in emergency department dizziness presentations: a population-based study. Otolaryngol Head Neck Surg 2013; 148 (03) 425-430
  • 114 Soto-Varela A, Rossi-Izquierdo M, Sánchez-Sellero I, Santos-Pérez S. Revised criteria for suspicion of non-benign positional vertigo. QJM 2013; 106 (04) 317-321
  • 115 Sarasin FP, Louis-Simonet M, Carballo D, Slama S, Junod AF, Unger PF. Prevalence of orthostatic hypotension among patients presenting with syncope in the ED. Am J Emerg Med 2002; 20 (06) 497-501
  • 116 Freeman R, Wieling W, Axelrod FB. , et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res 2011; 21 (02) 69-72
  • 117 Juraschek SP, Daya N, Rawlings AM. , et al. Association of history of dizziness and long-term adverse outcomes with early vs later orthostatic hypotension assessment times in middle-aged adults. JAMA Intern Med 2017; 177 (09) 1316-1323
  • 118 Choi JH, Seo JD, Kim MJ. , et al. Vertigo and nystagmus in orthostatic hypotension. Eur J Neurol 2015; 22 (04) 648-655
  • 119 Kim HA, Yi HA, Lee H. Recent advances in orthostatic hypotension presenting orthostatic dizziness or vertigo. Neurol Sci 2015; 36 (11) 1995-2002
  • 120 Fedorowski A, Burri P, Melander O. Orthostatic hypotension in genetically related hypertensive and normotensive individuals. J Hypertens 2009; 27 (05) 976-982
  • 121 Gilbert VE. Immediate orthostatic hypotension: diagnostic value in acutely ill patients. South Med J 1993; 86 (09) 1028-1032
  • 122 von Brevern M, Radtke A, Lezius F. , et al. Epidemiology of benign paroxysmal positional vertigo: a population based study. J Neurol Neurosurg Psychiatry 2007; 78 (07) 710-715
  • 123 Oghalai JS, Manolidis S, Barth JL, Stewart MG, Jenkins HA. Unrecognized benign paroxysmal positional vertigo in elderly patients. Otolaryngol Head Neck Surg 2000; 122 (05) 630-634
  • 124 Poon IO, Braun U. High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans. J Clin Pharm Ther 2005; 30 (02) 173-178
  • 125 Radtke A, Lempert T, von Brevern M, Feldmann M, Lezius F, Neuhauser H. Prevalence and complications of orthostatic dizziness in the general population. Clin Auton Res 2011; 21 (03) 161-168
  • 126 Wu JS, Yang YC, Lu FH, Wu CH, Chang CJ. Population-based study on the prevalence and correlates of orthostatic hypotension/hypertension and orthostatic dizziness. Hypertens Res 2008; 31 (05) 897-904
  • 127 Stark RJ, Wodak J. Primary orthostatic cerebral ischaemia. J Neurol Neurosurg Psychiatry 1983; 46 (10) 883-891
  • 128 Blank SC, Shakir RA, Bindoff LA, Bradey N. Spontaneous intracranial hypotension: clinical and magnetic resonance imaging characteristics. Clin Neurol Neurosurg 1997; 99 (03) 199-204
  • 129 Ward BK, Carey JP, Minor LB. Superior canal dehiscence syndrome: lessons from the first 20 years. Front Neurol 2017; 8: 177