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CC BY 4.0 · Rev Bras Ginecol Obstet 2019; 41(02): 084-089
DOI: 10.1055/s-0038-1676509
Original Article
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Pethidine in Low Doses versus Dipyrone for Pain Relief in Labor: A Randomized Controlled Trial

Petidina em doses baixas versus dipirona para alívio da dor no trabalho de parto: um ensaio clínico randomizado
Rogevando Rodrigues Nunes 
1   Graduate Program in Medical Sciences, Universidade de Fortaleza, Fortaleza, CE, Brazil
,
André Montenegro Primo
1   Graduate Program in Medical Sciences, Universidade de Fortaleza, Fortaleza, CE, Brazil
› Institutsangaben
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Publikationsverlauf

03. August 2018

22. Oktober 2018

Publikationsdatum:
20. Februar 2019 (online)

   Lizenzen und Reprints

Abstract

Objective To compare low doses of pethidine with dipyrone in labor analgesia.

Methods In a randomized prospective study conducted by Universidade de Fortaleza, in the state of Ceará, Brazil, between May and December 2016, 200 full-term parturients, with very painful uterine contractions and exhibiting uterine cervix dilatation ≥ 5 cm, were selected to receive a single intravenous dose of either 0.25 mg/kg of pethidine (n = 100) or of 25 mg/kg of dipyrone (n = 100). Pain was assessed using the visual analogue scale. The data were analyzed using the Student t-test, the chi-square test and the likelihood ratio.

Results There was a significant improvement in pain in 35% of the parturients. Both drugs presented a similar analgesic effect 1 hour after the intervention (p = 0.692). There was no analgesic effect during the evaluation of the second hour after the intervention with pethidine or dipyrone. There were no adverse effects, such as maternal drowsiness, nausea or vomiting, related to the drugs used.

Conclusion Pethidine in low doses and dipyrone presented equivalent analgesia during labor.

Public Registry of Clinical Trials RBR-4hsyy4.

Resumo

Objetivo Comparar doses baixas de petidina com dipirona na analgesia de parto.

Métodos Em um estudo prospectivo randomizado realizado pela Universidade de Fortaleza, Ceará, Brasil, entre maio e dezembro de 2016, 200 parturientes a termo, com contrações uterinas muito dolorosas e apresentando dilatação do colo uterino ≥ 5 cm, foram selecionadas para receber dose única intravenosa de 0,25 mg/kg de petidina (n = 100) ou 25 mg/kg de dipirona (n = 100). A dor foi avaliada pela escala visual analógica. Os dados foram analisados por meio dos testes t de Student, qui-quadrado e razão de verossimilhança.

Resultados Houve melhora significativa da dor em 35% das parturientes. Ambas as drogas apresentaram efeito analgésico semelhante 1 hora após a intervenção (p = 0.692). Inexistiu efeito analgésico durante a avaliação da segunda hora após a intervenção com a petidina ou com a dipirona. Não houve efeitos adversos, como sonolência, náuseas ou vômitos maternos, relacionados aos medicamentos utilizados.

Conclusão A petidina em doses baixas e a dipirona apresentaram analgesia equivalente durante o trabalho de parto.

Registro público de testes clínicos RBR-4hsyy4.

Keywords

analgesia - labor - dipyrone - pethidine - humanizing delivery

Palavras-chave

analgesia - trabalho de parto - dipirona - petidina - parto humanizado

Contributions

The authors developed planned, collected the data, and analyzed the results of the present research. Author who conducted the research: RRN. Authors who analyzed the data: RRN; AMP. Authors who wrote the paper: RRN; AMP.


 

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