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CC BY-NC-ND 4.0 · AJP Rep 2018; 08(04): e343-e348
DOI: 10.1055/s-0038-1676289
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue Tumors

Ernesto Antonio Figueiro-Filho
1   Division of Maternal-Fetal Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
,
Hythem Al-Sum
2   Division of Maternal-Fetal Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia
,
Jacqueline Parrish
1   Division of Maternal-Fetal Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
,
Jay S. Wunder
3   Musculoskeletal Oncology Unit, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
4   Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
,
Cynthia Maxwell
1   Division of Maternal-Fetal Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
› Author Affiliations
Funding None
Further Information

Publication History

20 September 2018

16 October 2018

Publication Date:
28 November 2018 (online)

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Abstract

Objective This study was aimed to describe perinatal outcome of a cohort of pregnant patients with bone and soft tissue tumors and to compare the current series with our group's previously reported experience.

Methods Pregnant women diagnosed before and during pregnancy were identified, retrospectively, for the years 2004 to 2014. Relevant maternal and neonatal data were collected.

Results Forty-eight patients were identified. Ten cases were diagnosed during pregnancy. Pelvis, abdomen, and extremities were the most common tumor locations. Osteosarcoma, liposarcoma, and Ewing's sarcoma were the most common histological types and comprise more than 50% of the cases. Metastases occurred in nine cases. Most of the cases (60%) were treated surgically during pregnancy and delivery occurred at term. Chemotherapy was delayed until after delivery. There were no perinatal or infant deaths. Patients presented with advanced maternal disease in 18% in previous report (1983–2003) versus 40% in present report (2004–2014). Metastases were present in 40% and maternal death rate was approximately 20% in both cohorts.

Conclusion Pregnant women with bone and soft tissue tumors are candidates for standard surgical management during pregnancy. Other treatments, such as chemotherapy and radiotherapy must be evaluated for each woman on a case-by-case basis. Iatrogenic prematurity was common in our findings.

Keywords

sarcomas - cancer - pregnancy - outcomes - perinatal

Précis

Pregnant women with sarcoma are candidates for surgical management during pregnancy. Chemotherapy and radiotherapy must be evaluated individually. Iatrogenic prematurity is a prominent risk.