Investigation of the Origin of Voltage Generation in Potentized Homeopathic Medicine through Raman Spectroscopy
22. Juli 2018
22. September 2018
07.Januar 2019 (eFirst)
Background For the study of homeopathic medicines in proper perspective, emerging techniques in material science are being used. Vibrational spectroscopy is one such tool for providing information on different states of hydrogen bonding as an effect of potentization. The associated change in electrical properties is also correlated with this effect.
Objective From the vibrational spectra, the changes in hydrogen bonding due to dilution followed by unidirectional vigorous shaking (together termed potentization) of 91% ethanol and two homeopathic medicines Chininum purum and Acidum benzoicum have been studied. The aim was to correlate the result with the change in the electrical properties of the system.
Methods Raman spectroscopy was used to study the vibrational spectra. A U-shaped glass tube (electrochemical cell), where one arm contained bi-distilled water and the other arm alcohol/homeopathic medicine (the arms being separated by a platinum foil), was used to measure the voltage generated across two symmetrically placed platinum electrodes.
Results For all samples, it was observed that potentization affected the intensity of OH stretching bands at the frequencies 3240 cm−1, 3420 cm−1 and 3620 cm−1, corresponding to strong hydrogen bond, weak hydrogen bond and broken hydrogen bond, respectively. With the increase in potency, in the presence and absence of the two medicines in ethanol, the number of OH groups linked by strong hydrogen bonds decreased, while the number of OH groups with weak hydrogen bonds increased. With the increase in potentization, the number of OH groups with broken hydrogen bonds showed a difference in the presence and absence of the medicine.
The voltage measurements for ethanol show that, with succussion, the magnitude of voltage increased with the two medicines at lower potencies, but not at higher potency where the voltage is lower. Acidum benzoicum, which is acidic in nature, had higher voltage values (113mV, 130 mV and 118 mV at 6C, 30C and 200C, respectively), compared with Chininum purum, which is basic in nature (20 mV, 85 mV and 65 mV at 6C, 30C and 200C, respectively).
Conclusion The experimental results indicate a correlation between the vibrational and electrical properties of the homeopathic medicines Acidum benzoicum and Chininum purum at different potencies.
KeywordsRaman spectroscopy - hydrogen bonding - voltage generation - homeopathic medicines - potentization
• We measured the different states of hydrogen bonding in Chininum purum (basic in nature) and Acidum bezoicum (acidic in nature) through Raman spectroscopy.
• We measured the ionic states of both homeopathic medicines through electrical measurements.
• We established a correlation between voltage measurement and Raman Spectroscopy by different strengths of hydrogen bonding.
• Our findings suggest that broken hydrogen bonds might play a vital role in the generation of the associated voltage in these medicines.
• This study might assist our understanding of the working mechanism of homeopathic medicines at different potencies.
- 1 Anick DJ, Ives JA. The silica hypothesis for homeopathy: physical chemistry. Homeopathy 2007; 96: 189-195
- 2 Bellavite P, Marzotto M, Olioso D, Moratti E, Conforti A. High-dilution effects revisited. 1. Physicochemical aspects. Homeopathy 2014; 103: 4-21
- 3 Nandy P. A review article of basic research on homeopathy from a physicist's point of view. Ind J Res Homoeopath 2015; 9: 141-151
- 4 Elia V, Germano R, Napoli E. Permanent dissipative structures in water: the matrix of life? Experimental evidences and their quantum origin. Curr Top Med Chem 2015; 15: 559-571
- 5 Konovalov AI, Ryzhkina IS. Formation of nano-associates as a key to understanding of physicochemical and biological properties of highly dilute aqueous solutions. Russ Chem Bull Int Ed 2014; 63: 1-14
- 6 Elia V, Napoli E, Germano R. The ‘Memory of Water’: an almost deciphered enigma. Dissipative structures in extremely dilute aqueous solutions. Homeopathy 2007; 96: 163-169
- 7 Konovalov AI. The formation of nanosized molecular ensembles in highly dilute aqueous solutions. Herald Russ Acad Sci 2013; 83: 513-519
- 8 Shah R. Standardization of the potentizing machine and quantification of impact of potentization. Ind J Res Homoeopath 2016; 10: 126-132
- 9 Kar S, Bandyopadhyay P, Chakraborty S. , et al. Derivation of an empirical relation between the size of the nanoparticle and the potency of homeopathic medicines. Int J High Dilution Res 2015; 14: 2-7
- 10 Klein S, Tournier A. Physicochemical investigations of homeopathic potencies: a systematic review of the literature. Eur J Integr Med 2016; 8: 27
- 11 Smekal A. Zur Quantentheoric der Dispersion. Naturwissenschaften 1923; 11: 873-875
- 12 Sarkar T, Konar A, Sukul NC, Singha A, Sukul A. Vibrational and Raman spectroscopy provide further evidence in support of free OH groups and hydrogen bond strength underlying difference in two more drugs at ultrahigh dilutions. Int J High Dilution Res 2016; 15: 2-10
- 13 Konar A, Sarkar T, Chakraborty I. , et al. Raman spectroscopy reveals variation in free OH groups and hydrogen bond strength in ultrahigh dilutions. Int J High Dilution Res 2016; 15: 2-9
- 14 Raman CV, Krishnan KS. A new type of secondary radiation. Nature 1928; 121: 501-502
- 15 Eisenberg D, Kauzmann W. The Structure and Properties of Water. Oxford: Clarendon Press; 1969
- 16 Burikov S, Dolenko T, Patsaeva S, Starokurov Y, Yuzhakov V. Raman and IR Spectroscopy Research on hydrogen bonding in water-ethanol systems. Mol Phys 2010; 108: 2427-2436
- 17 Burikov S, Dolenko TA, Fadeev VV, Vlasov I. Revelation of ion hydration in Raman Scattering spectral bands. Laser Phys 2007; 17: 1255-1261
- 18 Homeopathic Pharmacopoeia of India., Ministry of Health, Govt. of India. Available at: https://www.nhp.gov.in/Homeopathic-Pharamacopeia-of-India-(HPI)_mtl
- 19 Dolenko TA, Burikov SA, Patsaeva SV, Yuzhakov VI. Manifestation of hydrogen bonds of aqueous ethanol solutions in the Raman scattering spectra. Quantum Electron 2011; 41: 267-272
- 20 Sarkar T, Konar A, Sukul NC, Majumdar D, Singha A, Sukul A. Raman spectroscopy shows difference in drugs at ultrahigh dilution prepared with stepwise mechanical agitation. Int J High Dilution Res 2016; 15: 2-8
- 21 Pershin SM, Bunkin AF, Grishin MY. , et al. Correlation of optical activity and light scattering in ultra-low-concentrated phenosan–potassium aqueous solutions. Dokl Phys 2015; 60: 114-117
- 22 Pershin SM, Bunkin AF, Grishin MY, Lednev VN, Fedorov AN, Palmina NP. Bimodal dependence of light scattering/fluctuations on the concentration of aqueous solutions. Phys Wave Phenom 2016; 24: 1-7
- 23 Bandyopadhyay P, Bera D, Das K. , et al. Vigorous shaking enhances voltage and power generation in polar liquids due to domain formation as predicted by QED. Water 2017; 8: 172-182