Assisted Reproductive Technology and Epigenetics

Anthony M. DeAngelis; Anne E. Martini; Carter M. Owen

doi:10.1055/s-0038-1675780

Seminars in Reproductive Medicine, Inhaltsverzeichnis

Semin Reprod Med 2018; 36(03/04): 221-232
DOI: 10.1055/s-0038-1675780

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Assisted Reproductive Technology and Epigenetics

Anthony M. DeAngelis

¹Reproductive Biology and Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland

,

Anne E. Martini

¹Reproductive Biology and Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland

,

Carter M. Owen

²Colorado Center for Reproductive Medicine Northern Virginia, Vienna, Virginia

› Institutsangaben

Abstract

Assisted reproductive technology (ART) is responsible for 1.7% of births in the United States annually. Despite a large number of studies promoting the efficacy and safety of these practices, there have been reports of imprinting disorders occurring at higher frequencies in children born through ART. Driven by findings in animal studies, it has been postulated that various ART procedures employed at critical points in embryonic development may predispose the genomic imprinting process to errors. Alterations in DNA methylation patterns at imprinting control centers have been reported by some studies to occur more frequently in children with imprinting disorders conceived by ART compared with spontaneous conception, though these findings are not consistently demonstrated and controversy has surrounded the strength of these associations. The rarity of imprinting disorders with a reliance of studies on disease registry cohorts, wide variations in ART protocols, and a lack of proper control groups limit the ability to substantiate associations between imprinting disorders and ART. Large, prospective cohort studies with a focus on molecular etiologies of these conditions are needed to discern whether a true association exists. Based on current evidence, the absolute risk of imprinting disorders after ART is low and screening for imprinting disorders in children conceived by ART is not warranted.

Keywords

assisted reproductive technology - epigenetics - imprinting disorders

Volltext

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References
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