J Pediatr Infect Dis 2019; 14(03): 103-107
DOI: 10.1055/s-0038-1675582
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Tigecycline Use in Neonates: 5-Year Experience of a Tertiary Center

Mehmet Sah İpek
1  Division of Neonatology, Department of Pediatrics, Memorial Dicle Hospital, Diyarbakir, Turkey
,
Mehmet Emin Gunel
2  Department of Pediatrics, Memorial Dicle Hospital, Diyarbakir, Turkey
,
Erdal Ozbek
3  Department of Microbiology, Diyarbakir Maternity and Children Hospital, Diyarbakir, Turkey
› Author Affiliations
Further Information

Publication History

25 March 2018

26 September 2018

Publication Date:
09 November 2018 (eFirst)

Abstract

The off-label use of tigecycline to treat serious infections has been reported in pediatric patients. We report four newborn infants diagnosed with sepsis caused by extensively drug-resistant Klebsiella pneumoniae and successfully treated with tigecycline. If no alternative drugs are available, tigecycline may be considered as an option for nosocomial infections even in newborn infants. However, further reports are needed to establish its efficacy and safety.