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CC BY-NC-ND 4.0 · AJP Rep 2018; 08(04): e332-e334
DOI: 10.1055/s-0038-1675335
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Heterogeneous Presentation of Neonatal Hemochromatosis in Dichorionic Twins

Yee Yuet Chee
1   Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong, Hong Kong
,
Siu Chun Mabel Wong
1   Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong, Hong Kong
,
Ming Sum Rosanna Wong
1   Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong, Hong Kong
› Author Affiliations
Further Information

Publication History

31 January 2018

19 June 2018

Publication Date:
20 November 2018 (online)

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Abstract

Acute liver failure (ALF) in neonates is rare. Although the incidence is reported to be rare, neonatal hemochromatosis (NH) has to be considered as one of the causes of neonatal ALF. We present a pair of dichorionic twin who had a diverse clinical presentation of NH. One twin passed away despite medical treatment with exchange transfusion and intravenous immunoglobulin (IVIg), whereas the other twin suffered from only mildly deranged liver function, which normalized spontaneously. Early identification of liver failure and clinical awareness of this disease entity are essential to its timely diagnosis and treatment. Antenatal management using IVIg prevents the recurrence of NH in subsequent pregnancies.

Keywords

neonatal hemochromatosis - gestational alloimmune liver disease - liver failure
 

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