Thromb Haemost 2018; 118(11): 1962-1968
DOI: 10.1055/s-0038-1673402
Stroke, Systemic or Venous Thromboembolism
Georg Thieme Verlag KG Stuttgart · New York

Venous Thromboembolism in Women Undergoing Assisted Reproductive Technologies: Data from the RIETE Registry

Elvira Grandone
1  Thrombosis and Haemostasis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy
,
Pier Paolo Di Micco
2  Department of Internal Medicine, Ospedale Fatebenefratelli, Napoli, Italy
,
Michela Villani
1  Thrombosis and Haemostasis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy
,
Donatella Colaizzo
1  Thrombosis and Haemostasis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy
,
Carmen Fernández-Capitán
3  Department of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain
,
Jorge Del Toro
4  Department of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain
,
Vladimir Rosa
5  Department of Internal Medicine, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
,
Alessandra Bura-Riviere
6  Department of Vascular Medicine, Hôpital de Rangueil, Toulouse, France
,
Isabelle Quere
7  Department of Vascular Medicine, Hôpital Saint Eloi, Montpellier, France
,
Ángeles Blanco-Molina
8  Department of Internal Medicine, Hospital Universitario Reina Sofía, Córdoba, Spain
,
Maurizio Margaglione
9  Department of Medical Genetics, University of Foggia, Foggia, Italy
,
Manuel Monreal
10  Department of Internal Medicine, Hospital Universitario Germans Trias i Pujol de Badalona, Universidad Católica de Murcia, Barcelona, Spain
,
for the RIETE Investigators› Author Affiliations
Further Information

Publication History

04 August 2018

23 August 2018

Publication Date:
08 October 2018 (eFirst)

Abstract

Venous thromboembolism (VTE) during or after assisted reproductive technologies (ART) is predicted to rise due to the increased number of women undergoing this technique. We present data collected in the RIETE registry up to October 2016. Overall, 41 (0.6%) out of 6,718 women of childbearing age with VTE had an ART-related event. Most of them underwent autologous ART cycles; 23 had isolated deep vein thrombosis (DVT) (56.1%), 12 isolated pulmonary embolism (PE) (29.3%) and 6 simultaneous occurrence of both the events (14.6%). VTE occurred in 20 successful and 21 unsuccessful (i.e. not resulting in a clinical pregnancy) ART cycles. No recurrence was observed at 90 days. Logistic regression showed that isolated PE was significantly more frequent than DVT alone or combined with PE in unsuccessful in vitro fertilization (IVF) (odds ratio [OR]: 4.13, 95% confidence interval [CI]: 1.4–12.4), as well as in contraceptive users (OR: 2.96, 95% CI: 1.95–4.5) and in puerperium (OR: 1.96, 95% CI: 1.16–3.3). After grouping isolated PE and DVT + PE, we found that PE was significantly more frequent in women with unsuccessful IVF and higher body mass index (OR: 5.0, 95% CI: 1.2–20.7 and OR: 1.0, 95%CI: 1.0–1.1, respectively). These data document a higher risk of PE in unsuccessful cycles than in successful ones. The risk is higher than that observed during pregnancy, puerperium and contraception.

Supplementary Material