The impact of uterine artery embolization of fibroids and adenomyosis in lipid profile in symptomatic and premenopausal women

Aim:

Uterine fibroids are defined as benign neoplasms that originate from smooth muscle cells. UAE is a therapeutic method for treating fibroids. The purpose of UAE is to obstruct or reduce blood flow at the level of very small arteries thus creating an irreversible ischemic damage to fibroids and the objective of this study is to research the effect of UAE on the lipid profile of patients who underwent treatment with the method of embolization.

Materials and methods:

195 patients aged 38 – 49 years with a history of adenomyosis and uterine fibroids treated with synthetic analogues of gonadotrophin releasing hormone (triptorelin) from 4 – 6 months underwent uterine artery embolization. The impact of embolization on hormone and lipid profiles of these patients was assessed by determining levels of FSH, AMH, cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides in pre- and post-treatment blood serum.

The statistical method that has used was the SPSS 10 statistical packet and the x2 test usage.

Results:

There was statistically noteworthy decrease in the values of triglycerides (p < 0.001) and cholesterol (p < 0.001), an increase in HDL-cholesterol (p < 0.0001), while no statistically considerable change in LDL-cholesterol levels were observed. Regarding the hormonal profile were observed a progressively statistically significant increase on of levels of FSH and LH in the first postoperative month, reaching the maximum value, the third postoperative month Exception was found in AMH levels, where increased levels were observed from the third month.

Conclusion:

Lipid profile of patients improved and ovarian function was not affected.