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CC BY-NC-ND 4.0 · AJP Rep 2018; 08(03): e168-e173
DOI: 10.1055/s-0038-1669938
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Dexmedetomidine for Sedation of Neonates with HIE Undergoing Therapeutic Hypothermia: A Single-Center Experience

Keliana O'Mara
1   Department of Pharmacy, University of Florida Health Shands Hospital, University of Florida, Gainesville, Florida
,
Michael D. Weiss
2   Department of Pediatrics, University of Florida, Gainesville, Florida
› Author Affiliations
Further Information

Publication History

30 January 2018

24 April 2018

Publication Date:
04 September 2018 (online)

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Abstract

Hypoxic-ischemic encephalopathy (HIE) is a significant cause of morbidity and mortality in neonates. Therapeutic hypothermia reduces the risk of death or disability. Providing optimal sedation while neonates are undergoing therapeutic hypothermia is likely beneficial but may present therapeutic challenges. There are limited data describing the use of dexmedetomidine for sedation in patients undergoing therapeutic hypothermia. The objective of this study is to evaluate the efficacy and short-term safety of dexmedetomidine infusion for sedation in term neonates undergoing therapeutic hypothermia for HIE.

Keywords

hypoxic-ischemic encephalopathy - sedation - dexmedetomidine - neonate

Statement of Financial Support

Children's Miracle Network.


 

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