Download PDF
J Hand Microsurg 2019; 11(03): 154-156
DOI: 10.1055/s-0038-1669364
Case Report
Society of Indian Hand & Microsurgeons

A Case of Nonsyndromic Unilateral Cleft Hand with Central Polydactyly, Syndactyly, and Thumb Hypoplasia: Support for a Common Etiology

Alpay Duran
1   Department of Plastic, Reconstructive and Aesthetic Surgery, Sanliurfa Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey
,
Hasan Buyukdogan
2   Department of Plastic, Reconstructive and Aesthetic Surgery, Ankara University, Ankara, Turkey
› Author Affiliations Funding None.
Further Information

Publication History

Received: 07 November 2017

Accepted after revision: 28 May 2018

Publication Date:
27 September 2018 (online)

    Permissions and Reprints

Abstract

Experimental studies showed that central polydactyly, syndactyly, and cleft hand might appear when the same teratogenic factor acts on embryos at the same developmental stage. These observations and some clinical cases support the concept that a common etiologic mechanism is involved in the development of these malformations. We report a clinical case that demonstrates the association previously observed in experimental studies. Here, a patient with unilateral nonsyndromic cleft hand, central polydactyly, first web syndactyly, osseous syndactyly between the ring and long fingers, and minor thumb hypoplasia was presented.

Keywords

central polydactyly - cleft hand - syndactyly
 

  • References

  • 1 FSSH Scientific Committee on Congenital Conditions. Classification of Congenital Hand Upper Limb Anomalies, 2014. Available at: http://www.ifssh.info/Congenital_Conditions2014.pdf Accessed March 20, 2017
    PubMed
  • 2 Birch-Jensen A. Congenital Deformities of the Upper Extremities. 1st ed. Odense, Denmark: Andelsbogtrykkeriet i Odense; 1949
  • 3 Flatt AE. The Care of Congenital Hand Anomalies. St. Louis, MO: CV Mosby; 1977
  • 4 Ogino T, Minami A, Fukuda K, Kato H. Congenital anomalies of the upper limb among the Japanese in Sapporo. J Hand Surg [Br] 1986; 11 (03) 364-371
    CrossrefPubMedGoogle Scholar
  • 5 Ogino T. Teratogenic relationship between polydactyly, syndactyly and cleft hand. J Hand Surg [Br] 1990; 15 (02) 201-209
    CrossrefPubMedGoogle Scholar
  • 6 Naruse T, Takahara M, Takagi M, Ogino T. Early morphological changes leading to central polydactyly, syndactyly, and central deficiencies: an experimental study in rats. J Hand Surg Am 2007; 32 (09) 1413-1417
    CrossrefPubMedGoogle Scholar
  • 7 Naruse T, Takahara M, Takagi M, Oberg KC, Ogino T. Busulfan-induced central polydactyly, syndactyly and cleft hand or foot: a common mechanism of disruption leads to divergent phenotypes. Dev Growth Differ 2007; 49 (06) 533-541
    PubMedGoogle Scholar
  • 8 Manske PR, Halikis MN. Surgical classification of central deficiency according to the thumb web. J Hand Surg Am 1995; 20 (04) 687-697
    CrossrefPubMedGoogle Scholar
  • 9 Ogino T. Teratogenic mechanisms of congenital absence of digits. Locomotor system. Adv Res Diagn Ther 2011; 18: 173-193
    PubMedGoogle Scholar
  • 10 Miura T. Syndactyly and split hand. Hand 1976; 8 (02) 125-130
    CrossrefPubMedGoogle Scholar
  • 11 Manske PR. Cleft hand and central polydactyly in identical twins: a case report. J Hand Surg Am 1983; 8 (06) 906-908
    CrossrefPubMedGoogle Scholar
  • 12 Satake H, Ogino T, Takahara M. et al. Occurrence of central polydactyly, syndactyly, and cleft hand in a single family: report of five hands in three cases. J Hand Surg Am 2009; 34 (09) 1700-1703
    CrossrefPubMedGoogle Scholar
  • 13 Al-Qattan MM. Central and ulnar cleft hands: a review of concurrent deformities in a series of 47 patients and their pathogenesis. J Hand Surg Eur Vol 2014; 39 (05) 510-519
    CrossrefPubMedGoogle Scholar