Hamostaseologie 2019; 39(01): 095-099
DOI: 10.1055/s-0038-1668570
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Acquired Haemophilia A Associated with Subsequent Hepatocellular Carcinoma

Renata Pacholczak
1  Department of Anatomy, Jagiellonian University Medical College, Cracow, Poland
2  Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Cracow Branch, Poland
,
Stanisława Bazan-Socha
3  Department of Internal Medicine, Jagiellonian University Medical College, Cracow, Poland
,
Joanna Zdziarska
4  Department of Hematology, Jagiellonian University Medical College, Cracow, Poland
,
Teresa Iwaniec
3  Department of Internal Medicine, Jagiellonian University Medical College, Cracow, Poland
,
Jerzy A. Walocha
1  Department of Anatomy, Jagiellonian University Medical College, Cracow, Poland
,
Jacek Musiał
3  Department of Internal Medicine, Jagiellonian University Medical College, Cracow, Poland
,
Jerzy Dropiński
3  Department of Internal Medicine, Jagiellonian University Medical College, Cracow, Poland
› Author Affiliations
Further Information

Publication History

20 January 2018

23 May 2018

Publication Date:
15 August 2018 (eFirst)

Abstract

Acquired haemophilia A (AHA) is a rare autoimmune disease caused by antibodies directed against clotting factor VIII. About half of cases are idiopathic, but AHA may also be secondary to autoimmune, dermatologic, or oncologic diseases. In approximately 10% of non-idiopathic cases, the disease occurs after or with the diagnosis of cancer as an extremely rare paraneoplastic syndrome. We describe the case of a 73-year-old male patient diagnosed with AHA and successfully treated with recombinant human activated factor VIIa and immunosuppression. Two and a half years later, however, the disease relapsed and a routine ultrasound revealed a liver tumour that was then diagnosed as hepatocellular carcinoma. We present this case to increase awareness that this life-threatening condition may develop years prior to the diagnosis of cancer.

Authors' Contribution

Renata Pacholczak: conception of study, study design, acquisition of data, data analysis and interpretation, drafting of manuscript.


Stanisława Bazan-Socha: data analysis and interpretation, revising of manuscript.


Joanna Zdziarska: acquisition of data, revising of manuscript.


Teresa Iwaniec: data analysis and interpretation, revising of manuscript.


Jerzy A. Walocha: revising of manuscript, general supervision.


Jacek Musiał: revising of manuscript, general supervision.


Jerzy Dropiński: revising of manuscript, general supervision.