J Pediatr Infect Dis 2018; 13(04): 283-286
DOI: 10.1055/s-0038-1668534
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio May Be Used as Predictors in Febrile Seizures

Abdullah Yazar
1   Department of Pediatric Emergency, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
,
Fatih Akın
1   Department of Pediatric Emergency, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
,
Esra Türe
1   Department of Pediatric Emergency, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
,
Hüseyin Çaksen
2   Department of Pediatric Neurology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
,
Dursun Odabaş
1   Department of Pediatric Emergency, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
› Author Affiliations
Further Information

Publication History

29 January 2018

09 July 2018

Publication Date:
22 August 2018 (online)

Abstract

Febrile seizure (FS) is the most frequent seizure disorder in childhood, associated with rapid onset of high fever. Our study aims are (1) to determine if the levels of mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) are risk factors for FS and to (2) assess the usefulness of these markers as predictors to distinguish the subgroups of FS. This prospective study includes children with FS, acute febrile illness (AFI) without seizure, and control group. Complete blood count was performed on all participants. The following data were obtained: white blood cell count (WBC), platelet count, MPV, hemoglobin (Hb), absolute neutrophil count (ANC), absolute lymphocyte count (ALC), and NLR. MPV, WBC, ANC, and NLR were significantly increased in patients with AFI and FS compared with controls (p < 0.05). When patients with FS and AFI were compared, only WBC was increased significantly in patients with FS (p < 0.05). WBC, ANC, and NLR were significantly increased in patients with complex FS compared with simple (p < 0.05). Our findings showed that WBC, MPV, ANC, and NLR were higher in children with FS than in the control group. Additionally WBC, ANC, and NLR were found to be higher in children with CFS than in those with simple febrile seizure. Based on the study results, we suggest that only WBC may be used as predictors in children with FS.

Informed Consent

Informed consent was obtained from the parents of children included in the study.