J Pediatr Neurol 2019; 17(05): 161-167
DOI: 10.1055/s-0038-1667177
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Developmental Alterations of Cerebral Gray and White Matter in Children with Congenital Cyanotic Heart Disease

Juan Leon-Wyss
1  Cardio-vascular Center, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic
,
Cynthia Rosario
1  Cardio-vascular Center, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic
,
Janet Toribio
1  Cardio-vascular Center, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic
,
Herwin Speckter
2  Department of Radiology, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic
,
Bernd Foerster
2  Department of Radiology, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic
,
Jairo Oviedo
2  Department of Radiology, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic
,
Hans-Jürgen Huppertz
3  Swiss Epilepsy Clinic, Klinik Lengg AG, Zurich, Switzerland
,
Peter Stoeter
2  Department of Radiology, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic
› Author Affiliations
Further Information

Publication History

28 March 2018

07 June 2018

Publication Date:
15 August 2018 (eFirst)

Abstract

This article examines the relation between oxygen saturation and T2 star time in cyanotic congenital heart disease and its correlation to cerebral gray and white matter alterations. Magnetic resonance imaging was performed in 25 patients (mean age: 52.2 months) and 32 controls. Gray and white matter volumes, as well as fractional anisotropy and longitudinal diffusivity, were significantly reduced in patients. The reduction longitudinal diffusivity correlated to oxygen saturation and T2 star time of gray matter (p < 0.05). This diffusion tensor imaging (DTI) parameter was most affected in cyanotic congenital heart disease and because is the only parameter showing significant correlation to reduced oxygenation, it should be included more often in the follow-up of these patients over time.