Role of Preoperative Embolization for Hypervascular Cherubism

Cherubism is an autosomal dominant condition, first described by Jones in three siblings who presented with a fullness of the cheeks and enlargement of the jaws.[1] The characteristic appearance closely resembled the Renaissance cherubs inspiring Jones to name it as cherubism.[2] [3] The condition is a fibro-osseous dysplasia characterized by painless symmetrical enlargement of the jaws. The mean age at the time of presentation is 7 years with a range of 12 months to 14 years.[4] The condition has a 100% penetrance in males and 50 to 70% in females.[5] In this article, we describe the role of angiography and embolization for a rare hypervascular variant of cherubism prior to surgical therapy.

• References

• 1 Jones WA. Familial multilocular cystic disease of the jaws. Am J Cancer 1933; 17 (04) 946-950
• 2 Waldron CA. Bone pathology. In: Neville BW, Damm DD, Allen CM. et al, eds. Oral and Maxillofacial Pathology. Philadelphia, PA: Saunders; 1995: 456-458
• 3 Kalantar MotamediMH. Treatment of cherubism with locally aggressive behavior presenting in adulthood: report of four cases and a proposed new grading system. J Oral Maxillofac Surg 1998; 56 (11) 1336-1342
• 4 Riefkohl R, Georgiade GS, Georgiade NG. Cherubism. Ann Plast Surg 1985; 14 (01) 85-90
• 5 Zachariades N, Papanicolaou S, Xypolyta A, Constantinidis I. Cherubism. Int J Oral Surg 1985; 14 (02) 138-145
• 6 Yamaguchi T, Dorfman HD, Eisig S. Cherubism: clinicopathologic features. Skeletal Radiol 1999; 28 (06) 350-353
• 7 Regezi JA, Sciubba J. Oral Pathology: Clinical-Pathologic Correlations. 2nd ed.. Philadelphia, PA: Saunders; 1993: 345-354
• 8 Seward GR, Hankey GT. Cherubism. Oral Surg Oral Med Oral Pathol 1957; 10 (09) 952-974
• 9 Brannin DE, Christensen RO. Bilateral giant cell tumors of the mandible in siblings; report of cases. J Oral Surg (Chic) 1954; 12 (03) 247-251
• 10 Hamner III JE, Ketcham AS. Cherubism: an analysis of treatment. Cancer 1969; 23 (05) 1133-1143
• 11 Khosla VM, Korobkin M. Cherubism. Am J Dis Child 1970; 120 (05) 458-461
• 12 Koury ME, Stella JP, Epker BN. Vascular transformation in cherubism. Oral Surg Oral Med Oral Pathol 1993; 76 (01) 20-27
• 13 Meng XM, Yu SF, Yu GY. Clinicopathologic study of 24 cases of cherubism. Int J Oral Maxillofac Surg 2005; 34 (04) 350-356
• 14 Kaugars GE, Niamtu III J, Svirsky JA. Cherubism: diagnosis, treatment, and comparison with central giant cell granulomas and giant cell tumors. Oral Surg Oral Med Oral Pathol 1992; 73 (03) 369-374
• 15 Topazian RG, Costich ER. Familial fibrous dysplasia of the jaws (cherubism): report of a case. J Oral Surg 1965; 23: 559-568
• 16 Lannon DA, Earley MJ. Cherubism and its charlatans. Br J Plast Surg 2001; 54 (08) 708-711
• 17 Hitomi G, Nishide N, Mitsui K. Cherubism: diagnostic imaging and review of the literature in Japan. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 81 (05) 623-628
• 18 Henry F, Testelin S, Gauvin AC, Poirier J, Henry E. [Cherubism: the value of imaging and preoperative embolization] [in French]. J Radiol 2003; 84 (11) Pt 1 1774-1778