Semin Liver Dis 2018; 38(03): 193-214
DOI: 10.1055/s-0038-1666869
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Potential Mechanisms Underlying the Role of Coffee in Liver Health

Louise J. M. Alferink
1  Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
,
Jessica C. Kiefte-de Jong
2  Department of Epidemiology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
3  Global Public Health, Leiden University College, The Hague, The Netherlands
,
Sarwa Darwish Murad
1  Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

Publication Date:
24 July 2018 (online)

Abstract

Coffee, the most consumed hot beverage worldwide, is composed of many substances, of which polyphenols, caffeine, and diterpenoids are well studied. Evidence on potential effects of coffee on human health has been accumulating over the past decades. Specifically, coffee has been postulated to be hepatoprotective in several epidemiological and clinical studies. Several underlying molecular mechanisms as to why coffee influences liver health have been proposed. In this review, the authors summarized the evidence on potential mechanisms by which coffee affects liver steatosis, fibrosis, and hepatic carcinogenesis. The experimental models reviewed almost unanimously supported the theorem that coffee indeed may benefit the liver. Either whole coffee or its specific compounds appeared to decrease fatty acid synthesis (involved in steatogenesis), hepatic stellate activation (involved in fibrogenesis), and hepatic inflammation. Moreover, coffee was found to induce apoptosis and increased hepatic antioxidant capacity, which are involved in carcinogenesis.

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