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Thromb Haemost 1997; 78(06): 1495-1499
DOI: 10.1055/s-0038-1665440
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Schattauer GmbH Stuttgart

Small, Dense LDL Particle Concentration Correlates with Plasminogen Activator Inhibitor Type-1 (PAI-1) Activity

Sari Väisänen
1   The Kuopio Research Institute of Exercise Medicine and Department of Physiology, Kuopio University, Finland
,
Manfred W Baumstark
2   Department of Rehabilitation, Prevention and Sports Medicine, Freiburg University, Germany
,
Ilkka Penttilä
3   Department of Clinical Chemistry, Kuopio University Hospital, Finland
,
Claude Bouchard
4   Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, Canada
,
Pirjo Halonen
5   Computing Centre, Kuopio University, Finland
,
Tuomo Rankinen
1   The Kuopio Research Institute of Exercise Medicine and Department of Physiology, Kuopio University, Finland
,
Aloys Berg
2   Department of Rehabilitation, Prevention and Sports Medicine, Freiburg University, Germany
,
Rainer Rauramaa
1   The Kuopio Research Institute of Exercise Medicine and Department of Physiology, Kuopio University, Finland
› Author Affiliations
Further Information

Publication History

Received 04 1997

Accepted after revision 16 July 1997

Publication Date:
12 July 2018 (online)

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Summary

The relation between LDL subtractions and fibrinolytic activity was studied in 150 men aged 53 to 63 years. Apolipoprotein B (apoB) concentration in the most dense LDL-5 (r = 0.39, p <0.001) and LDL-6 (r = 0.43, p <0.001) subtractions associated with plasminogen activator inhibitor type-1 (PAI-1) activity. Subjects in the highest LDL-6 apoB tortile had higher PAI-1 (24.7 vs. 13.1 AU/ml, p <0.001) and lower t-PA (0.26 vs. 0.54 IU/ml, p <0.001) activities than men in the lowest tortile. The difference in PAI-1 remained after adjusting for either triglycerides (p = 0.039) or insulin (p = 0.015) with cardiorespiratory fitness as an additional covariate, and history of cardiovascular disease and smoking as factors. In a regression analysis, plasma insulin and LDL-6 apoB, but not plasma triglycerides and body mass index, entered the model, and explained 30.6 and 3.9 % of the variance in PAI-1 activity, respectively. The novel finding of the present study was the independent association between small, dense LDL particles and PAI-1 activity in middle-aged men.

 

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