Thromb Haemost 1997; 78(06): 1430-1433
DOI: 10.1055/s-0038-1665428
Rapid Communication
Schattauer GmbH Stuttgart

Prevalence of the Prothrombin Gene Variant (nt20210A) in Venous Thrombosis and Arterial Disease

Valder R Arruda
1   The Hematology-Hemotherapy Center, State University of Campinas, Campinas-SP, Brazil
,
Joyce M Annichino-Bizzacchi
1   The Hematology-Hemotherapy Center, State University of Campinas, Campinas-SP, Brazil
,
Marilda S Gonçalves
2   Federal University of Bahia, Salvador-BA, Brazil
,
Fernando F Costa
1   The Hematology-Hemotherapy Center, State University of Campinas, Campinas-SP, Brazil
› Author Affiliations
Further Information

Publication History

Received 05 1997

Accepted 04 August 1997

Publication Date:
12 July 2018 (online)

Summary

The prothrombin gene variant resulting form a G→A transition at position 20210 has been described as a common genetic risk factor for venous thrombosis. However, the risk for developing arterial disease is unknown. In this investigation, we studied 116 patients with venous thrombosis and 71 with arterial disease, all of whom were compared with 295 controls. Additionally, we also investigated the distribution of the prothrombin alleles among African descendents and Amazonian Indians from Brazil. The prevalence of 0.7% for 20210A allele in the control group increased to 4.3% (P = 0.021) among patients with venous thrombosis. There was also a high prevalence of the mutated allele in a selected arterial disease group (5.7%) without hyperlipoproteinemia, hypertension, and diabetes mellitus when compared to the controls (P = 0.013). Heterozygotes for the allele 20210A were common among individuals of African descent (2%) and rare among Indians. These data support the hypothesis that the prothrombin variant is a risk factor for venous thrombosis and suggest that it may also be a risk factor for arterial disease.

 
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